{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:53:39Z","timestamp":1775289219832,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Depletion of myelin and neurobehavioural deficits are indications that vanadium crosses the blood\u2010brain barrier and such neurotoxic effects of vanadium on the brain of Wistar rats have been elucidated. The effect however on the peripheral nerves, is yet to be reported. Thus, this work was designed to evaluate the axonal and myelin integrity of sciatic nerves in Wistar rats following exposure to vanadium.<\/jats:p>\n                  <jats:p>Ten male Wistar rats were exposed to 3 mg\/kg body weight of sodium metavanadate for 7 days, subjected to rearing and forelimb grip behavioural tests, and sciatic nerves processed for histology (haematoxylin and eosin, cresyl violet, and luxol fast blue). Dystrophic axons with vesiculated myelin, thinned myelin sheath, and demyelinated axons were observed in the vanadium exposed rats, suggestive of axonopathy, classified as fourth\u2010degree nerve injury. Lower behavioural scores were recorded for vanadium\u2010dosed rats; thus, corroborating histological pictures observed of the sciatic nerves. Authors posit that vanadium crossed the \u201cblood\u2010nerve\u201d barrier and caused the observed axonal pathologies and myelin depletion in the sciatic nerves of these rodents with resultant motor deficits. The present paper discusses possible motor deficits and the likely public health importance in regions with crude oil pollution and gas flaring rich in vanadium products.<\/jats:p>","DOI":"10.1111\/jns.12294","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T22:50:28Z","timestamp":1543445428000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Peripheral axonopathy in sciatic nerve of adult Wistar rats following exposure to vanadium"],"prefix":"10.1111","volume":"24","author":[{"given":"Oluwaseun A.","family":"Mustapha","sequence":"first","affiliation":[{"name":"Neuroscience Unit, Department of Veterinary Anatomy College of Veterinary Medicine, Federal University of Agriculture Abeokuta Nigeria"},{"name":"Neuroscience Unit, Department of Veterinary Anatomy, Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Olude","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Department of Veterinary Anatomy College of Veterinary Medicine, Federal University of Agriculture Abeokuta Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Biosciences, Federal University of Agriculture Abeokuta Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayobami","family":"Taiwo","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Department of Veterinary Anatomy College of Veterinary Medicine, Federal University of Agriculture Abeokuta Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afusat","family":"Jagun","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James O.","family":"Olopade","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Department of Veterinary Anatomy, Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","first-page":"1","article-title":"Methods for global survey of natural gas flaring from visible infrared imaging radiometer suite data","volume":"9","author":"Elvidge C","year":"2016","journal-title":"Energies"},{"key":"e_1_2_6_3_1","volume-title":"World Bank's Global Gas Flaring Reduction Partnership (GGFR): Global Gas Flaring Observed from Space","author":"National Oceanic and Atmospheric Administration","year":"2017"},{"key":"e_1_2_6_4_1","volume-title":"Brochure: Global Gas Flaring Reduction Partnership (GGFR)","author":"World Bank","year":"2011"},{"key":"e_1_2_6_5_1","volume-title":"Estimated Flared Volumes from Satellite Data, 2007\u20132011","author":"World Bank","year":"2011"},{"key":"e_1_2_6_6_1","unstructured":"National Oceanic and Atmospheric Administration.2012.http:\/\/www.eia.gov\/countries\/analysisbriefs\/Nigeria\/images\/gas_flaring.png. 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