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However, soon after their introduction into clinical practice, chemotherapy\u2010induced peripheral neurotoxicity (CIPN) emerged as their main non\u2010hematological and among dose\u2010limiting adverse events. It is generally perceived that vinca alkaloids and the antiangiogenic agent thalidomide are more neurotoxic, compared to eribulin. The exposure to these chemotherapeutic agents is associated with an axonal, length\u2010dependent, sensory polyneuropathy of mild to moderate severity, whereas it is considered that the peripheral nerve damage, unless severe, usually resolves soon after treatment discontinuation. Advanced age, high initial and prolonged dosing, coadministration of other neurotoxic chemotherapeutic agents and pre\u2010existing neuropathy are the common risk factors. Pharmacogenetic biomarkers might be used to define patients at increased susceptibility of CIPN. Currently, there is no established therapy for CIPN prevention or treatment; symptomatic treatment for neuropathic pain and dose reduction or withdrawal in severe cases is considered, at the cost of reduced cancer therapeutic efficacy. This review critically examines the pathogenesis, epidemiology, risk factors (both clinical and pharmacogenetic), clinical phenotype and management of CIPN as a result of exposure to vinca alkaloids, thalidomide and its analogue lenalidomide as also eribulin.<\/jats:p>","DOI":"10.1111\/jns.12334","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T16:43:23Z","timestamp":1571935403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Vinca alkaloids, thalidomide and eribulin\u2010induced peripheral neurotoxicity: From pathogenesis to treatment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-944X","authenticated-orcid":false,"given":"Badrul","family":"Islam","sequence":"first","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research  Dhaka 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