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Epothilones share similar mechanism of action with taxanes. The typical TIPN clinical presentation is mainly comprised of numbness and paresthesia, in a stocking\u2010and\u2010glove distribution and may progress more proximally over time, with paclitaxel being more neurotoxic than docetaxel. Motor and autonomic involvement is less common, whereas an acute taxane\u2010induced acute pain syndrome is frequent. Patient reported outcomes questionnaires, clinical evaluation, and instrumental tools offer complementary information in TIPN. Its electrodiagnostic features include reduced\/abolished sensory action potentials, and less prominent motor involvement, in keeping with a length\u2010dependent, axonal <jats:italic>dying back<\/jats:italic> predominately sensory neuropathy. TIPN is dose\u2010dependent and may be reversible within months after the end of chemotherapy. The single and cumulative delivered dose of taxanes is considered the main risk factor of TIPN development. Apart from the cumulative dose, other risk factors for TIPN include demographic, clinical, and pharmacogenetic features with several single\u2010nucleotide polymorphisms potentially linked with increased susceptibility of TIPN. There are currently no neuroprotective strategies to reduce the risk of TIPN, and symptomatic treatments are very limited. This review critically examines the pathogenesis, incidence, risk factors (both clinical and pharmacogenetic), clinical phenotype and management of TIPN.<\/jats:p>","DOI":"10.1111\/jns.12336","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T16:43:23Z","timestamp":1571935403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Taxane and epothilone\u2010induced peripheral neurotoxicity: From pathogenesis to treatment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-2187","authenticated-orcid":false,"given":"Stefano","family":"Tamburin","sequence":"first","affiliation":[{"name":"Department of Neurosciences Biomedicine and Movement Sciences, University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-4707","authenticated-orcid":false,"given":"Susanna 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