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Despite the favorable results in terms of oncological outcomes, these treatments have been associated with a variety of immune\u2010related adverse events (irAEs). Neurological irAEs are rare but potentially severe. Neuromuscular disorders represent the most common neurological irAEs following anti\u2010PD\u20101, anti\u2010PD\u2010L1, and anti\u2010CTLA\u20104 treatment, and include myositis, myasthenia gravis, and demyelinating polyradiculoneuropathy. Instrumental findings may differ from typical neuromuscular disorders occurring outside ICIs treatment. Despite initial severity, neurological irAEs often respond to immune\u2010modulating therapies. Prompt irAEs diagnosis, ICIs discontinuation, and early treatment with corticosteroids, together with patient education and a multi\u2010disciplinary approach, are important for optimizing clinical outcomes. Intravenous immunoglobulin, plasma exchange, and other immune\u2010modulating treatments should be considered in more severe cases. Consideration of re\u2010challenging with the same immunotherapy drug may be given in some cases, based on clinical picture and initial severity of irAEs.<\/jats:p>","DOI":"10.1111\/jns.12339","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T15:09:32Z","timestamp":1565276972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Immune checkpoint inhibitors\u2010induced neuromuscular toxicity: From pathogenesis to treatment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-288X","authenticated-orcid":false,"given":"Dimitri","family":"Psimaras","sequence":"first","affiliation":[{"name":"AP\u2010HP, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re\u2014Charles Foix, Service de Neurologie Mazarin  Paris France"},{"name":"Inserm U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau 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