{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:33:53Z","timestamp":1790688833899,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008561","name":"Burnet Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001336","name":"University of the Witwatersrand, Johannesburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sensory neuropathy (SN) is a common and often painful neurological condition associated with HIV\u2010infection and its treatment. However, data on the incidence of SN in neuropathy\u2010free individuals initiating combination antiretroviral therapies (cART) that do not contain the neurotoxic agent stavudine are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated the 6\u2010month incidence of SN in ART na\u00efve individuals initiating tenofovir (TDF)\u2010based cART, and the clinical factors associated with the development of SN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>120 neuropathy\u2010free and ART na\u00efve individuals initiating cART at a single center in Johannesburg, South Africa were enrolled. Participants were screened for SN using clinical signs and symptoms at study enrolment and approximately every 2\u2010months for a period of ~6\u2010months. Diagnostic criteria for symptomatic SN was defined by the presence of at least one symptom (pain\/burning, numbness, paraesthesias) and at least two clinical signs (reduced vibration sense, absent ankle reflexes or pin\u2010prick hypoaesthesia). Diagnostic criteria for asymptomatic SN required at least two clinical signs only (as above).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 88% of the cohort completed three visits within the 6\u2010month period. The 6\u2010month cumulative incidence of neuropathy was 140 cases per 1000 patients (95% CI: 80\u2010210) at an incidence rate of 0.37 (95% CI: 0.2\u20100.5) per person year. Height and active tuberculosis (TB) disease were independently associated with the risk of developing SN (<jats:italic>P<\/jats:italic> &lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>We found that within the first 6 months of starting cART, incident SN persists in the post\u2010stavudine era, with 11 (9%) of individuals developing asymptomatic SN, and 9 (8%) developing symptomatic SN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12349","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T09:03:36Z","timestamp":1570352616000},"page":"304-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Clinical diagnosis of sensory neuropathy in HIV patients treated with tenofovir: A 6\u2010month follow\u2010up study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-3071","authenticated-orcid":false,"given":"Prinisha","family":"Pillay","sequence":"first","affiliation":[{"name":"Brain Function Research Group, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia L.","family":"Wadley","sequence":"additional","affiliation":[{"name":"Brain Function Research Group, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Cherry","sequence":"additional","affiliation":[{"name":"Brain Function Research Group, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"},{"name":"Burnet Institute  Melbourne Australia"},{"name":"Department of Infectious Diseases Alfred Hospital and Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Karstaedt","sequence":"additional","affiliation":[{"name":"Department of Medicine Chris Hani Baragwanath Hospital  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Kamerman","sequence":"additional","affiliation":[{"name":"Brain Function Research Group, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"},{"name":"School of Pharmacy and Biomedical Sciences Curtin University  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874613601610010034"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30086-3"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.CON.0000423849.24900.ec"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00169"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-012-0257-z"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.06.014"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.05.002"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31823e31f7"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014433"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460356.94374.a1"},{"key":"e_1_2_18_12_1","unstructured":"World Health Organization.Towards universal access: scaling up HIV\/AIDS interventions in the health sector.2009.http:\/\/www.who.int\/hiv\/pub\/arv\/rapid_advice_art.pdfAccessed November 4 2010."},{"key":"e_1_2_18_13_1","first-page":"1","volume-title":"Guidelines for Managing Advanced HIV Disease and Rapid Initiation of Antiretroviral Therapy","author":"World Health Organization","year":"2017"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063596"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-183"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2016.25.14.9699"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-1306"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182097505"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.15.0467"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-71"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25710"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000149522.32823.EA"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.07.031"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000492"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187119.33075.41"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21535"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.07.006"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164994"},{"key":"e_1_2_18_29_1","unstructured":"PillayP.The incidence of peripheral neuropathy in HIV\u2010Positive individuals on highly active antiretroviral therapy (HAART).2011. Available at:http:\/\/hdl.handle.net10539\/13726."},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000461252.75089.bf"},{"issue":"2","key":"e_1_2_18_31_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/135965350801300203","article-title":"The risk of developing peripheral neuropathy induced by nucleoside reverse transcriptase inhibitors decreases over time: evidence from the delta trial","volume":"13","author":"Arenas\u2010Pinto A","year":"2008","journal-title":"Antivir Ther"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2008.0128"},{"key":"e_1_2_18_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jana.2009.10.003"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.76"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2012.00373.x"},{"key":"e_1_2_18_36_1","doi-asserted-by":"crossref","unstructured":"CentnerCM CarraraH HarrisonTB BenatarM HeckmannJM.Sensory polyneuropathy in human immunodeficiency virus\u2010infected patients receiving tuberculosis treatment.2014;18:27\u201033.","DOI":"10.5588\/ijtld.13.0375"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.7196\/samj.6455"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-9-35"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2016.03.002"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-017-0356-x"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211354"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328345889d"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-017-1856-9"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjns.12349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jns.12349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T13:42:36Z","timestamp":1694180556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,28]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jns.12349"],"URL":"https:\/\/doi.org\/10.1111\/jns.12349","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,28]]},"assertion":[{"value":"2019-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}