{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:13:35Z","timestamp":1794014015470,"version":"4.8.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010659","name":"Erasmus Universitair Medisch Centrum Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["734584"],"award-info":[{"award-number":["734584"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Zika virus (ZIKV) epidemic in Brazil in 2015\u20102016 was followed by an increase in the incidence of patients with Guillain\u2010Barr\u00e9 syndrome (GBS). With this national survey study, we aimed to gain a better understanding of how neurologists in Brazil are currently diagnosing and treating patients with GBS, and how this increase in incidence has impacted the management of the disease. The questionnaire consisted of 52 questions covering: personal profile of the neurologist, practice of managing GBS during and outside of the ZIKV epidemic, and limitations in managing GBS. All 3264 neurologists that were member of the Brazilian Academy of Neurology at the time of the study were invited to participate. The questionnaire was fully answered by 171 (5%) neurologists. Sixty\u2010one percent of neurologists noticed an increase in patients with GBS during the ZIKV epidemic, and 30% experienced an increase in problems in managing GBS during this time. The most important limitations in the diagnosis and management of GBS included the availability of nerve conduction studies (NCS), beds in the Intensive Care Unit (ICU) and referral to rehabilitation centers. Most neurologists did not use a protocol for treating patients with GBS and the treatment practice varied. Increasing availability of NCS and beds in the ICU and rehabilitation centers, and the implementation of (inter)national guidelines, are critical in supporting Brazilian neurologist in their management of GBS, and are especially important in preparing for future outbreaks.<\/jats:p>","DOI":"10.1111\/jns.12358","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T08:35:17Z","timestamp":1574238917000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnosis and treatment of Guillain\u2010Barr\u00e9 syndrome during the Zika virus epidemic in Brazil: A national survey study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-6926","authenticated-orcid":false,"given":"Sonja E.","family":"Leonhard","sequence":"first","affiliation":[{"name":"Department of Neurology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo M.","family":"Conde","sequence":"additional","affiliation":[{"name":"Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (FMRP\u2010USP)  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"de Assis Aquino Gondim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Neurology Division Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Immunology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324710"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1110"},{"key":"e_1_2_9_6_1","unstructured":"World Health Organization.Zika situation report February 5 2016.World Health Organization.2016:https:\/\/www.who.int\/emergencies\/zika-virus\/situation-report\/5-february-2016\/en\/."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605564"},{"key":"e_1_2_9_8_1","unstructured":"Pan American Health Organization.Zika suspected and confirmed cases reported by countries and territories in the Americas Cumulative cases. Washington DC: Pan American Health Organization; 2015\u20132017. Updated as of January 4 2018."},{"key":"e_1_2_9_9_1","volume-title":"Zika \u2010 Epidemiological Report Brazil","author":"Pan American Health Organization","year":"2017"},{"key":"e_1_2_9_10_1","unstructured":"Protocolos Cl\u00ednicos e Diretrizes Terap\u00eauticas \u2010 PCDT Sindrome de Guillain\u2010Barr\u00e9.2015:http:\/\/www.saude.gov.br\/protocolos\u2010e\u2010diretrizes."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.003"},{"key":"e_1_2_9_12_1","first-page":"565","article-title":"Criteria for diagnosis of Guillain\u2010Barr\u00e9 syndrome","volume":"3","author":"Asbury AK","year":"1978","journal-title":"Ann Neurol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007719"},{"key":"e_1_2_9_15_1","unstructured":"Organisation for economic co\u2010operation and development (OECD).2019:https:\/\/data.oecd.org\/brazil.htm."},{"key":"e_1_2_9_16_1","article-title":"Boletim Epidemiol\u00f3gico, Monitoramento dos casos de dengue, febre de chikungunya e febre pelo v\u00edrus Zika at\u00e9 a Semana Epidemiol\u00f3gica 52, 2016 [Epidemiologic Bulletin, Monitoring of dengue, chikungunya and Zika virus cases until epidemiologic week 52, 2016]","volume":"48","author":"Secretaria de Vigil\u00e2ncia em Sa\u00fade Minist\u00e9rio da Sa\u00fade","year":"2017","journal-title":"Boletim Epidemiol\u00f3gico"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.09.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00279-16"},{"key":"e_1_2_9_19_1","first-page":"CD001798","article-title":"Plasma exchange for Guillain\u2010Barr\u00e9 syndrome","volume":"2","author":"Chevret S","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_20_1","first-page":"CD002063","article-title":"Intravenous immunoglobulin for Guillain\u2010Barr\u00e9 syndrome","volume":"7","author":"Hughes RA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2019.02.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0250-9"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jns.12358","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T13:42:16Z","timestamp":1694180536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/jns.12358"],"URL":"https:\/\/doi.org\/10.1111\/jns.12358","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}