{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:00:57Z","timestamp":1790744457513,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cold intolerance and pain can be a substantial problem in patients with peripheral nerve injury. We aimed at investigating the relationships among sensory recovery, cold intolerance, and neuropathic pain in patients affected by upper limb peripheral nerve injury (Sunderland type V) treated with microsurgical repair, followed by early sensory re\u2010education. In a cross\u2010sectional clinical study, 100 patients (male\/female 81\/19; age 40.5\u2009\u00b1\u200914.8\u2009years and follow\u2010up 17\u2009\u00b1\u20095 months, mean\u2009\u00b1\u2009SD), with microsurgical nerve repair and reconstruction in the upper extremity and subsequent early sensory re\u2010education, were evaluated, using Cold Intolerance Symptoms Severity questionnaire\u2010Italian version (CISS\u2010it, cut\u2010off pathology &gt;30\/100 points), CISS questionnaire\u201012 item version (CISS\u201012, 0\u201046 points\u2010grouping: healthy that means no cold intolerance [0\u201014], mild [15\u201024], moderate [25\u201034], severe [35\u201042], very severe [43\u201046] cold intolerance), probability of neuropathic pain (DouleurNeuropathique\u20104; [DN4] 4\/10), deep and superficial sensibility, tactile threshold (monofilaments), and two\u2010point discrimination (cutoff S2; Medical Research Council scale for sensory function; [MRC\u2010scale]). A high CISS score is associated with possible neuropathic pain (DN4\u2009\u2265\u20094). Both a low CISS\u2010it score (ie, &lt;\u200930) and DN4\u2009&lt;\u20094 is associated with good sensory recovery (MRC\u2009\u2265\u20092). In conclusion patients affected by upper limb peripheral nerve injuries with higher CISS scores more often suffer from cold intolerance and neuropathic pain, and the better their sensory recovery is, the less likely they are to suffer from cold intolerance and neuropathic pain.<\/jats:p>","DOI":"10.1111\/jns.12376","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T03:28:20Z","timestamp":1587007700000},"page":"184-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cold intolerance and neuropathic pain after peripheral nerve injury in upper extremity"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9667-6210","authenticated-orcid":false,"given":"Ernesta","family":"Magistroni","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Traumatology and Physical Medicine and Rehabilitation, Physical Medicine and Rehabilitation Academic Unit, Traumatologic Orthopaedic Center Citta' della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Parodi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Traumatology and Physical Medicine and Rehabilitation, Physical Medicine and Rehabilitation Academic Unit, Traumatologic Orthopaedic Center Citta' della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Fop","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Renal Transplant Center \u201cA. Vercellone,\u201d Nephrology, Dialysis and Renal Transplant Division \u201cCitta' della Salute e della Scienza di Torino\u201d University Hospital, Universita' degli Studi di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Battiston","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Traumatology and Physical Medicine and Rehabilitation, Hand and Microsurgery Unit, Traumatologic Orthopaedic Center Citta' della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars B.","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"},{"name":"Department of Translational Medicine\u2010Hand Surgery Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.2.160071"},{"key":"e_1_2_7_3_1","volume-title":"Post\u2010Traumatic Cold Sensitivity in Median and Ulnar Nerve Injury Patients: Subjective and Objective Findings","author":"Ruijs AC","year":"2009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-89"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHSB.2007.02.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2018.01.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(97)80448-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(85)90003-8"},{"key":"e_1_2_7_9_1","volume-title":"Cold Intolerance: From Thermoregulation to Nerve Innervation","author":"Smits ES","year":"2013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(85)90004-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-9053(05)80430-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(97)80392-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.19.05555-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHSB.2006.04.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MRR.0000000000000328"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(02)00303-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"e_1_2_7_18_1","volume-title":"Surgery of the Peripheral Nerve","author":"MacKinnon SE","year":"1988"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2006.01653.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0415-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2012.04.001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(94)90209-7"},{"key":"e_1_2_7_23_1","volume-title":"Median and Ulnar Nerve Injuries: Prognosis and Predictors for Clinical Outcome. 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