{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:25:51Z","timestamp":1783113951785,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The symptomatology of Charcot\u2010Marie\u2010Tooth (CMT) disease mainly involves the feet and the hands. To date, there is no consensus on how to evaluate hand function in CMT. The aim of this study is to correlate the data of the engineered glove Hand Test System (HTS) with specific tests and the CMT examination score (CMTES). We analyzed 45 patients with the diagnosis of CMT using HTS, which measures the hand dexterity by specific sequences performed at maximum velocity. We completed the evaluation with the CMTES, tripod pinch and hand grip strength tested by a dynamometer, thumb opposition test (TOT), and Sollerman Hand function test (SHFT), and we conducted a test\u2010retest with 20 normal subjects. Finger tapping (FT) and index\u2010medium\u2010ring\u2010little (IMRL) sequence showed a significant correlation with CMTES (FT: dominant hand (DH): <jats:italic>P<\/jats:italic> = .036; non\u2010dominant hand (NDH): <jats:italic>P<\/jats:italic> = .033; IMRL: DH: <jats:italic>P<\/jats:italic> = .009; NDH: <jats:italic>P<\/jats:italic> = .046). TOT correlated with CMTES significantly in both hands (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). tripod pinch showed a statistically significant correlation with CMTES (DH: <jats:italic>P<\/jats:italic> = .002; NDH: <jats:italic>P<\/jats:italic> = .005). Correlation between the hand grip and CMTES was significant only in DH (DH: <jats:italic>P<\/jats:italic> = .002). SHFT had a significant correlation with the CMTES (DH: <jats:italic>P<\/jats:italic> = .002). Test\u2010retest showed a good reliability. HTS parameters correlate with CMTES confirming that this tool is sensitive to the hand deficits. In conclusion, we can state that HTS is a good, simple to use, and objective instrument to evaluate the hand function of CMT patients, but more studies on responsiveness and sensitivity are needed.<\/jats:p>","DOI":"10.1111\/jns.12421","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T05:26:30Z","timestamp":1604381190000},"page":"413-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Validation of a new hand function outcome measure in individuals with <scp>Charcot\u2010Marie\u2010Tooth<\/scp> disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-0576","authenticated-orcid":false,"given":"Valeria","family":"Prada","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Infantile Sciences (DINOGMI) University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Robbiano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Infantile Sciences (DINOGMI) University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Mennella","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Infantile Sciences (DINOGMI) University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnaz","family":"Hamedani","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Infantile Sciences (DINOGMI) University of Genova  Genova 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Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-7899","authenticated-orcid":false,"given":"Riccardo","family":"Zuccarino","sequence":"additional","affiliation":[{"name":"University of Iowa  Iowa City Iowa USA"},{"name":"Fondazione Serena Onlus Centro Clinico Nemo  Arenzano 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