{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:32:37Z","timestamp":1747186357200,"version":"3.40.5"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral nerve injuries caused by focal constriction are characterised by local nerve ischaemia, axonal degeneration, demyelination, and neuroinflammation. The aim of this study was to understand temporal changes in the excitability properties of injured motor axons in a mouse model of nerve constriction injury (NCI). The excitability of motor axons following unilateral sciatic NCI was studied in male C57BL\/6J mice distal to the site of injury at the acute (6 hours\u20101 week) and chronic (up to 20\u2009weeks) phases of injury, using threshold tracking. Multiple measures of nerve excitability, including strength\u2010duration properties, threshold electrotonus, current\u2010threshold relationship, and recovery cycle were examined using the automated nerve excitability protocol (TRONDNF). Acutely, injured motor axons developed a pattern of excitability characteristic of ischemic depolarisation. In most cases, the sciatic nerve became transiently inexcitable. When a liminal compound muscle action potential could again be recorded, it had an increase in threshold and latency, compared to both pre\u2010injury baseline and sham\u2010injured groups. These axons showed a greater threshold change in response to hyperpolarising threshold electrotonus and a significant upward shift in the recovery cycle. Mathematical modelling suggested that the changes seen in chronically injured axons involve shortened internodes, reduced myelination, and exposed juxtaparanodal fast K<jats:sup>+<\/jats:sup> conductances. The findings of this study demonstrate long\u2010term changes in motor excitability following NCI (involving alterations in axonal properties and ion channel activity) and are important for understanding the mechanisms of neurapraxic injuries and traumatic mononeuropathies.<\/jats:p>","DOI":"10.1111\/jns.12430","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:54:01Z","timestamp":1610693641000},"page":"99-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrophysiological investigation of motor axonal excitability in a mouse model of nerve constriction injury"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-4253","authenticated-orcid":false,"given":"Preet G. S.","family":"Makker","sequence":"first","affiliation":[{"name":"Translational Neuroscience Facility, School of Medical Sciences The University of New South Wales (UNSW)  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke A.","family":"Keating","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Facility, School of Medical Sciences The University of New South Wales (UNSW)  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin G.","family":"Lees","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Facility, School of Medical Sciences The University of New South Wales (UNSW)  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Burke","sequence":"additional","affiliation":[{"name":"Central Clinical School, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Howells","sequence":"additional","affiliation":[{"name":"Central Clinical School, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3828-9527","authenticated-orcid":false,"given":"Gila","family":"Moalem\u2010Taylor","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Facility, School of Medical Sciences The University of New South Wales (UNSW)  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-3039-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2017.08.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2017.87"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4260.237"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/74.4.491"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200110000-00011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02844310500340046"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010450"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35097557"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.143424"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013806"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(93)90281-F"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000020635.41233.0f"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.09.020"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.08.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.04.021"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00385-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050583"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn332"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13047"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.069443"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.069476"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.10.016"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2009.00205.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200003)23:3<399::AID-MUS12>3.0.CO;2-G"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.06.092"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014064"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.225573"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12278"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00260.2020"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.01.018"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.12.2542"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.4.1657"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.67.5.1385"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4040-14.2015"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012478"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.4.1929"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.9.865"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00323"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1639"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32834c208d"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1482-4"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(82)90182-4"},{"key":"e_1_2_8_45_1","first-page":"62","article-title":"Conduction in regenerating nerve fibres distal to a constriction","volume":"317","author":"Gilliatt RW","year":"1981","journal-title":"J Physiol"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24501"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2013.04.002"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2006.01654.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90065-5"},{"key":"e_1_2_8_50_1","first-page":"433","article-title":"Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet","volume":"113","author":"Ochoa J","year":"1972","journal-title":"J Anat"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(74)90158-0"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.34.3.243"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.3.340"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.933"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.09.027"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.11.006"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200004)23:4<498::AID-MUS7>3.0.CO;2-U"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.01.022"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jns.12430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T19:02:07Z","timestamp":1693681327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,20]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/jns.12430"],"URL":"https:\/\/doi.org\/10.1111\/jns.12430","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"type":"print","value":"1085-9489"},{"type":"electronic","value":"1529-8027"}],"subject":[],"published":{"date-parts":[[2021,1,20]]},"assertion":[{"value":"2020-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}