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They retrospectively included 54 patients meeting Camdessanch\u00e9 et al (2009) criteria for sensory neuronopathy. The patients were classified according to their likely aetiology and analysed their demographic, clinical, neurophysiological, histological and spinal MRI features. The outcome with the modified Rankin Scale (mRS) was evaluated, and the response to treatment was assessed. About 54 patients were included (18 male; median age 54.5\u2009years). The most common initial symptoms were hypoaesthesia, paraesthesia, ataxia and pain. Half of patients had a slow onset, greater than 12\u2009months before seeing a neurologist. The aetiology as possibly inflammatory (meaning nonspecific laboratory evidence of immune abnormality) in 18 patients (33%), paraneoplastic 8 (15%), autoimmune 7 (13%) and idiopathic 6 (11%) was classified. About 31 patients received immune therapy of which 11 (35%) improved or stabilised. Corticosteroids were the most used treatment (24 patients) and cyclophosphamide had the highest response rate (3\/6, 50%). At the final follow up (median 24\u2009months) 67% had mRS \u22653 and 46% mRS \u22654, including 15% who died. Worse outcome was associated with generalised areflexia and pseudoathetosis by logistic regression, and with motor involvement and raised CSF protein by univariate analysis. Sensory neuronopathies caused severe disability, especially in patients with generalised areflexia and pseudoathetosis. Of those without an obvious cause, most had some evidence of dysimmunity. Some patients had a positive response to immunotherapy, but rarely enough to improve disability much.<\/jats:p>","DOI":"10.1111\/jns.12433","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T20:43:51Z","timestamp":1611521031000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sensory neuronopathies: A case series and literature review"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-9436","authenticated-orcid":false,"given":"Agustin","family":"Sancho Salda\u00f1a","sequence":"first","affiliation":[{"name":"Department of Neurology King's College Hospital NHS Foundation Trust  Denmark Hill London UK"},{"name":"Department of Neurology Hospital Universitario Miguel Servet  Zaragoza 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