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There is a need for better understanding of the molecular mechanisms that underlie long\u2010term suboptimal nerve function and for approaches to prevent or improve it. In this communication we describe our studies using whole animal electrophysiology to examine the long\u2010term sequelae of sciatic nerve crush in both WT and Cx32KO mice, a model of X\u2010linked Charcot Marie Tooth disease, a subtype of inherited peripheral neuropathies. We present results from electrical nerve recordings done 14 to 27\u2009days and 18 to 20\u2009months after a unilateral sciatic nerve crush performed on 35 to 37\u2010day old mice. Contrary to expectations, we find that whereas crush injury leads to a degradation of WT nerve function relative to uninjured nerves at 18 to 20\u2009months, previously crushed Cx32KO nerves perform at the same level as their uninjured counterparts. Thus, 18 to 20\u2009months after injury, WT nerves perform below the level of normal (uninjured) WT nerves in both motor and sensory nerve function. In contrast, measures of nerve function in Cx32KO mice are degraded for sensory axons but exhibit no additional dysfunction in motor axons. Early nerve injury has no negative electrophysiologic effect on the Cx32 KO motor nerves. Based on our prior demonstration that the transcriptomic profile of uninjured Cx32KO and injured WT sciatic nerves are very similar, the lack of an additional effect of crush on Cx32KO motor nerve parameters suggests that Cx32 knockout may implement a form of neuroprotection that limits the effects of subsequent injury.<\/jats:p>","DOI":"10.1111\/jns.12436","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T08:30:10Z","timestamp":1614155410000},"page":"167-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of early crush on aging wild type and Connexin 32 knockout mice: Evidence for a neuroprotective state in <scp>CMT1X<\/scp> mouse nerve"],"prefix":"10.1111","volume":"26","author":[{"given":"Alejandro","family":"Peinado","sequence":"first","affiliation":[{"name":"Department of Neurology and Rehabilitation College of Medicine, University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha L.","family":"Asche\u2010 Godin","sequence":"additional","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J. 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