{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:44:48Z","timestamp":1769877888648,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the distinctive features (with images and video) of a case of chronic inflammatory demyelinating polyneuropathy (CIDP) with giant nerves. The main clinical findings were insidious onset, gait ataxia and sensory symptoms. Electrodiagnostic studies showed very slow nerve conduction velocities, multiple conduction blocks, distal CMAP duration increase and absence of F\u2010waves. The protein level in the cerebrospinal fluid was very high. Nerve ultrasound showed swelling of all peripheral nerves outside entrapment sites, with significant variability within different segments of the same nerve; nerves were massively enlarged (up to 10\u2010fold normal values). Brain MRI showed hypertrophic cranial nerves, with gadolinium\u2010enhancement. Spinal MRI showed hypertrophy of spinal roots and cauda equine, with gadolinium enhancement. Genetic test (PMP22 duplication\/deletion, Whole Exome Sequencing panel for neuropathies) resulted negative. The patient had a relapsing\u2010remitting course and responded to immunoglobulin treatment. In CIDP with hypertrophic nerves, there is discrepancy between severe nerve hypertrophy and mild clinical symptoms. Nerve enlargement seems inversely related to nerve conduction velocity and directly correlated with disease duration, but not associated with disease severity.<\/jats:p>","DOI":"10.1111\/jns.12445","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:24:56Z","timestamp":1619051096000},"page":"227-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic inflammatory demyelinating polyneuropathy with hypertrophic nerves"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-9656","authenticated-orcid":false,"given":"Paolo","family":"Ripellino","sequence":"first","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland  Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Ventura","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Neurocenter of Southern Switzerland  Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Querol","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital de la Santa Creu i Sant Pau, Institut de Recerca Biom\u00e8dica Sant Pau  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland  Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera Italiana (USI)  Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02930.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21431"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199602)19:2<163::AID-MUS6>3.0.CO;2-C"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199607)19:7<892::AID-MUS12>3.0.CO;2-L"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199806)21:6<805::AID-MUS16>3.0.CO;2-R"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.01.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25272"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jns.12445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T08:40:28Z","timestamp":1692866428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,26]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/jns.12445"],"URL":"https:\/\/doi.org\/10.1111\/jns.12445","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,26]]},"assertion":[{"value":"2020-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}