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Several arbovirus infections have been associated with Guillain\u2010Barr\u00e9 syndrome (GBS). We investigated whether arboviruses are driving GBS beyond epidemic phases of transmission and studied the antibody response to glycolipids. The protocol of the International Guillain\u2010Barr\u00e9 syndrome Outcome Study (IGOS), an observational prospective cohort study, was adapted to a case\u2010control design. Serum samples were tested for a recent infection with Zika virus (ZIKV), dengue virus (DENV), chikungunya (CHIKV) virus, hepatitis E virus, Epstein\u2010Barr virus (EBV), cytomegalovirus (CMV), <jats:italic>Campylobacter jejuni<\/jats:italic>, and <jats:italic>Mycoplasma pneumoniae<\/jats:italic>, and for antibodies to glycolipids. Forty\u2010nine patients were included from Brazil (63%), Argentina (14%), and Malaysia (22%). Evidence of a recent infection was found in 27\/49 (55%) patients: <jats:italic>C jejuni<\/jats:italic> (n\u00a0=\u00a015, 31%), <jats:italic>M pneumoniae<\/jats:italic> (n\u00a0=\u00a05, 10%), CHIKV (n\u00a0=\u00a02, 4%), EBV (n\u00a0=\u00a01, 2%), <jats:italic>C jejuni<\/jats:italic> and <jats:italic>M pneumoniae<\/jats:italic> (n\u00a0=\u00a02, 4%), CMV and DENV (n\u00a0=\u00a01, 2%), and <jats:italic>C jejuni<\/jats:italic> and DENV (n\u00a0=\u00a01, 2%). In 22 patients, 35 paired controls were collected. Odds ratio for recent infections did not significantly differ between cases and controls. No typical anti\u2010ganglioside antibody binding was associated with recent arbovirus infection. We conclude that arbovirus infections occur in GBS patients outside of epidemic viral transmission, although not significantly more than in controls. Broad infection and anti\u2010ganglioside antibody serology are important to establish the most likely pathogenic trigger in GBS patients. 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