{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:35Z","timestamp":1787015495936,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/3\/JRF\u20102015\/HRD\u2010LS\/49\/40754\/122"],"award-info":[{"award-number":["3\/1\/3\/JRF\u20102015\/HRD\u2010LS\/49\/40754\/122"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Guillain\u2010Barr\u00e9 syndrome (GBS) is the commonest post\u2010infectious polyradiculopathy. Although genetic background of the host seems to play an important role in the susceptibility to GBS, genes conferring major risk are not yet known. Dysregulation of Toll\u2010like receptor (TLR) molecules exacerbates immune\u2010inflammatory responses and the genetic variations within TLR pathway\u2010related genes contribute to differential risk to infection. The aim of this study was to delineate the impact of genetic variations within\n                    <jats:italic>TLR2<\/jats:italic>\n                    ,\n                    <jats:italic>TLR3<\/jats:italic>\n                    , and\n                    <jats:italic>TLR4<\/jats:italic>\n                    genes as well as TLR signaling pathway\u2010related genes such as\n                    <jats:italic>MyD88<\/jats:italic>\n                    ,\n                    <jats:italic>TRIF<\/jats:italic>\n                    ,\n                    <jats:italic>TRAF3<\/jats:italic>\n                    ,\n                    <jats:italic>TRAF6<\/jats:italic>\n                    ,\n                    <jats:italic>IRF3<\/jats:italic>\n                    ,\n                    <jats:italic>NF\u03ba\u03b21<\/jats:italic>\n                    , and\n                    <jats:italic>I\u03baB\u03b1<\/jats:italic>\n                    on risk of developing GBS. Fourteen polymorphisms located within\n                    <jats:italic>TLR2<\/jats:italic>\n                    (rs3804099, rs111200466),\n                    <jats:italic>TLR3<\/jats:italic>\n                    (rs3775290, rs3775291),\n                    <jats:italic>TLR4<\/jats:italic>\n                    (rs1927911, rs11536891),\n                    <jats:italic>MyD88<\/jats:italic>\n                    (rs7744, rs4988453),\n                    <jats:italic>TRIF<\/jats:italic>\n                    (rs8120),\n                    <jats:italic>TRAF3<\/jats:italic>\n                    (rs12147254),\n                    <jats:italic>TRAF6<\/jats:italic>\n                    (rs4755453),\n                    <jats:italic>IRF3<\/jats:italic>\n                    (rs2304204),\n                    <jats:italic>NF\u03ba\u03b21<\/jats:italic>\n                    (rs28362491), and\n                    <jats:italic>I\u03baB\u03b1<\/jats:italic>\n                    (rs696) genes were genotyped in 150 GBS patients and 150 healthy subjects either by PCR\u2010RFLP or TaqMan Allelic Discrimination Assay. Genotypes of two polymorphic variants, Del\/Del of rs111200466 insertion and deletion (INDEL) polymorphism of\n                    <jats:italic>TLR2<\/jats:italic>\n                    gene and TT of rs3775290 single nucleotide polymorphism (SNP) of\n                    <jats:italic>TLR3<\/jats:italic>\n                    gene had significantly higher frequencies among GBS patients, while the frequencies of TT genotype of rs3804099 SNP of\n                    <jats:italic>TLR2<\/jats:italic>\n                    gene and TT genotype of rs11536891 SNP of\n                    <jats:italic>TLR4<\/jats:italic>\n                    gene were significantly higher in controls. Gene\u2010gene interaction study by Multifactor Dimensionality Reduction analysis also suggested a significant combined effect of\n                    <jats:italic>TLR2<\/jats:italic>\n                    , and\n                    <jats:italic>NF\u03ba\u03b21<\/jats:italic>\n                    genes on the risk of GBS. The SNPs in the\n                    <jats:italic>I\u03baB\u03b1<\/jats:italic>\n                    and\n                    <jats:italic>IRF3<\/jats:italic>\n                    genes correlated with severity of GBS. The genes encoding TLRs and TLR signaling pathway\u2010related molecules could serve as crucial genetic markers of susceptibility and severity of GBS.\n                  <\/jats:p>","DOI":"10.1111\/jns.12484","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T06:24:44Z","timestamp":1644387884000},"page":"131-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Variations within Toll\u2010like receptor (\n                    <scp>TLR<\/scp>\n                    ) and\n                    <scp>TLR<\/scp>\n                    signaling pathway\u2010related genes and their synergistic effects on the risk of\n                    <scp>Guillain\u2010Barr\u00e9<\/scp>\n                    syndrome"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-3067","authenticated-orcid":false,"given":"Debprasad","family":"Dutta","sequence":"first","affiliation":[{"name":"Department of Human Genetics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-4577","authenticated-orcid":false,"given":"Madhu","family":"Nagappa","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binu V.","family":"Sreekumaran Nair","sequence":"additional","affiliation":[{"name":"Department of Biostatistics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biostatistics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Wahatule","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjib","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-7207","authenticated-orcid":false,"given":"Ravi","family":"Vasanthapuram","sequence":"additional","affiliation":[{"name":"Department of Neurovirology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore 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