{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:31:51Z","timestamp":1790188311293,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014255","name":"Fonds de dotation CSL Behring pour la recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014255","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical trials in chronic inflammatory demyelinating polyneuropathy (CIDP) often assess efficacy using the ordinal Inflammatory Neuropathy Cause and Treatment (INCAT) disability score. Here, data from the PATH study was reanalyzed using change in Inflammatory Rasch\u2010built Overall Disability Scale (I\u2010RODS) to define CIDP relapse instead of INCAT. The PATH study comprised an intravenous immunoglobulin (IVIG) dependency period and an IVIG (IgPro10 [Privigen]) restabilization period; subjects were then randomized to weekly maintenance subcutaneous immunoglobulin (SCIG; IgPro20 [Hizentra]) 0.2\u00a0g\/kg or 0.4\u00a0g\/kg or placebo for 24\u2009weeks. CIDP relapse was defined as \u22651\u2010point deterioration in adjusted INCAT, with a primary endpoint of relapse or withdrawal rates. This retrospective exploratory analysis redefined relapse using I\u2010RODS via three different cut\u2010off methods: an individual variability method, fixed cut\u2010off of \u22658\u2010point deterioration on I\u2010RODS centile score or \u22654\u2010point deterioration on I\u2010RODS raw score. Relapse or withdrawal rates were 47% for placebo, 34% for 0.2\u00a0g\/kg IgPro20 and 19% for 0.4\u00a0g\/kg IgPro20 using the raw score; 40%, 28% and 15%, respectively using the centile score, and 49%, 40% and 27%, respectively using the individual variability method. IgPro20 was shown to be efficacious as a maintenance therapy for CIDP when relapse was defined using I\u2010RODS. A stable response pattern was shown for I\u2010RODS across various applied cut\u2010offs, which could be applied in future clinical trials.<\/jats:p>","DOI":"10.1111\/jns.12487","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T09:15:53Z","timestamp":1646903753000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of relapse by inflammatory Rasch\u2010built overall disability scale status in the <scp>PATH<\/scp> study of subcutaneous immunoglobulin in chronic inflammatory demyelinating polyneuropathy"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-2361","authenticated-orcid":false,"given":"Ingemar S. J.","family":"Merkies","sequence":"first","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Department of Neurology Cura\u00e7ao Medical Center  Willemstad Cura\u00e7ao"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-6664","authenticated-orcid":false,"given":"Ivo N.","family":"van Schaik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Amsterdam University Medical Centers University of Amsterdam  Amsterdam the Netherlands"},{"name":"Board Department of the Hospital Spaarne Gasthuis  Haarlem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-4883","authenticated-orcid":false,"given":"Vera","family":"Bril","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) University Health Network, University of Toronto  Toronto Canada"},{"name":"Institute for Research and Medical Consultations Imam Abdulrahman Bin Faisal University  Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0614-6989","authenticated-orcid":false,"given":"Hans\u2010Peter","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Neurology, UKD and Center for Neurology and Neuropsychiatry, LVR Klinikum, Medical Faculty Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Department of Neurology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-5922","authenticated-orcid":false,"given":"Gen","family":"Sobue","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-176X","authenticated-orcid":false,"given":"John\u2010Philip","family":"Lawo","sequence":"additional","affiliation":[{"name":"Clinical Development Department CSL Behring  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4047-8175","authenticated-orcid":false,"given":"Orell","family":"Mielke","sequence":"additional","affiliation":[{"name":"Clinical Development Department CSL Behring  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-489X","authenticated-orcid":false,"given":"David R.","family":"Cornblath","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PATH study 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