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While most cases were described in populations with Caucasian ancestry, genetic research on CMT in Africa is scant. Only a few cases of CMT have been reported, mainly from North Africa. The current study aimed to summarise available data on CMT in Africa, with emphasis on the epidemiological, clinical, and genetic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Scopus, Web of Sciences, and the African Journal Online for articles published from the database inception until April 2021 using specific keywords. A total of 398 articles were screened, and 28 fulfilled our selection criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 107 families totalling 185 patients were reported. Most studies were reported from North Africa (n\u00a0=\u00a022). The demyelinating form of CMT was the commonest subtype, and the phenotype varied greatly between families, and one family (1%) of CMT associated with hearing impairment was reported. The inheritance pattern was autosomal recessive in 91.2% (n\u00a0=\u00a097\/107) of families. CMT\u2010associated variants were reported in 11 genes: <jats:italic>LMNA<\/jats:italic>, <jats:italic>GDAP1<\/jats:italic>, <jats:italic>GJB1<\/jats:italic>, <jats:italic>MPZ<\/jats:italic>, <jats:italic>MTMR13<\/jats:italic>, <jats:italic>MTMR2<\/jats:italic>, <jats:italic>PRX<\/jats:italic>, <jats:italic>FGD4\/FRABIN<\/jats:italic>, <jats:italic>PMP22<\/jats:italic>, <jats:italic>SH3TC2<\/jats:italic>, and <jats:italic>GARS<\/jats:italic>. The most common genes reported are <jats:italic>LMNA<\/jats:italic>, <jats:italic>GDAP1<\/jats:italic>, and <jats:italic>SH3TC2<\/jats:italic> and have been found mostly in Northern African populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study reveals that CMT is not rare in Africa, and describes the current clinical and genetic profile. The review emphasised the urgent need to invest in genetic research to inform counselling, prevention, and care for CMT in numerous settings on the continent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12489","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T08:28:04Z","timestamp":1649147284000},"page":"100-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Current profile of <scp>Charcot\u2010Marie\u2010Tooth<\/scp> disease in Africa: A systematic review"],"prefix":"10.1111","volume":"27","author":[{"given":"Abdoulaye","family":"Yalcouy\u00e9","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine et d'Odontostomatologie USTTB  Bamako Mali"},{"name":"Division of Human Genetics, Department of Pathology, Faculty of Health Sciences University of Cape Town  Cape Town South 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