{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:48:33Z","timestamp":1781754513830,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2019SF\u2010227"],"award-info":[{"award-number":["2019SF\u2010227"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The early clinical features of nitrous oxide (N<jats:sub>2<\/jats:sub>O)\u2010induced neuropathy were mimicking that of Guillain\u2010Barr\u00e9 syndrome (GBS). We aimed to explore clinical and laboratory characteristics of N<jats:sub>2<\/jats:sub>O\u2010induced neuropathy in comparison with GBS. We retrospectively reviewed data of 15 patients with N<jats:sub>2<\/jats:sub>O\u2010induced neuropathy and compared them with 15 GBS patients. The age of the N<jats:sub>2<\/jats:sub>O\u2010induced neuropathy group was significantly younger than that in the GBS group (22\u2009\u00b1\u20095 vs 45\u2009\u00b1\u200917). Paresthesia was more common in N<jats:sub>2<\/jats:sub>O\u2010induced neuropathy group (100% vs 53.3%). The proportion of distal upper limbs weakness was lower than that in GBS group (20.0% vs 93.3%). There was no significant difference in the distal weakness of the lower limbs (100% vs 80.0%). The incidence of motor conduction block and compound muscle action potential amplitude reduction in upper limbs was lower than that in GBS group (6.7% vs 60.0%; 26.7% vs 80.0%). The sensory nerve action potential amplitude drop in the lower limbs was more severe than that in GBS group (53.3% vs 0). The increase of Mean corpuscular volume (MCV) was more pronounced compared to GBS group (96.97\u2009\u00b1\u20096.00 vs 88.55\u2009\u00b1\u20095.41). High homocysteine levels were more common in N<jats:sub>2<\/jats:sub>O\u2010related group [29.80(11.60, 70.50) vs 14.35(9.22, 19.30)]. Typical clinical features of the acute N<jats:sub>2<\/jats:sub>O neuropathy appears to be a myeloneuropathy, affecting the lower limbs more than the upper limbs, mixed axonal\u2010demyelinating electrophysiological performance, higher homocysteine level, and larger MCV and common posterior spinal cord involvement in cervical segment.<\/jats:p>","DOI":"10.1111\/jns.12503","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T06:30:03Z","timestamp":1653460203000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acute nitrous oxide\u2010induced neuropathy mimicking <scp>Guillain\u2010Barr\u00e9<\/scp> syndrome"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-9740","authenticated-orcid":false,"given":"Xing","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoting","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi People's Republic of 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