{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:30:36Z","timestamp":1761921036055,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vaccinations against the severe acute respiratory syndrome coronavirus 2 which causes COVID\u201019 have been administered worldwide. We aimed to investigate associations of COVID\u201019 vaccination with the occurrence of Guillain\u2010Barr\u00e9 syndrome (GBS). We explored potential safety signals regarding the development of GBS using disproportionality analyses to compare COVID\u201019 vaccination with all adverse drug reaction (ADR) reports and influenza vaccines reported to VigiBase. As of October 15, 2021, a total of 2163 cases (0.13%) of GBS and its variants (including 46 cases of Miller\u2010Fisher syndrome and 13 cases of Bickerstaff's encephalitis) were identified in entire ADR database after vaccination with the ChAdOx1 nCoV\u201019 (AstraZeneca, Cambridge, UK) or the two messenger RNA\u2010based COVID\u201019 (BNT162b2; Pfizer and BioNTech) or mRNA\u20101273; Moderna) vaccines. The median time to onset of GBS after vaccination was around 2\u2009weeks. The ChAdOx1 nCoV\u201019 and two messenger RNA\u2010based COVID\u201019 vaccines demonstrated a higher risk for GBS against entire database (information component [IC]<jats:sub>025<\/jats:sub>\u00a0=\u00a01.73 reporting odds ratio [ROR]<jats:sub>025<\/jats:sub>\u00a0=\u00a03.51; IC<jats:sub>025<\/jats:sub>\u00a0=\u00a01.07, ROR<jats:sub>025<\/jats:sub>\u00a0=\u00a02.22, respectively). When compared with influenza vaccines, neither the ChAdOx1 nCoV\u201019 nor mRNA\u2010based vaccines were found to be associated with greater risks of GBS (IC<jats:sub>025<\/jats:sub>\u00a0=\u00a0\u22121.84, ROR<jats:sub>025<\/jats:sub>\u00a0=\u00a00.11; IC<jats:sub>025<\/jats:sub>\u00a0=\u00a0\u22121.86, ROR<jats:sub>025<\/jats:sub>\u00a0=\u00a00.06, respectively). Although potential safety signals associated with GBS COVID\u201019 vaccines have been identified, the risk of GBS from COVID\u201019 vaccines were low and did not surpass those of influenza vaccines; however, because of the heterogeneity of the sources of information in the WHO pharmacovigilance database, further epidemiological studies are warranted to confirm these observations.<\/jats:p>","DOI":"10.1111\/jns.12507","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T08:23:01Z","timestamp":1656145381000},"page":"206-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations of Guillain\u2010Barr\u00e9 syndrome with coronavirus disease 2019 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance database"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-3479","authenticated-orcid":false,"given":"Jee\u2010Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul Hospital, Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Hospital, Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Gi","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon\u2010Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Seoul Metropolitan Government Boramae Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-762X","authenticated-orcid":false,"given":"Tae\u2010Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Hospital, Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07370-x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200195"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27647"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27435"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.20892"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011881"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10081030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000184748"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13569"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00517-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112795"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00596-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26144"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26143"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327027"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2712.211634"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05733-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.16496"},{"key":"e_1_2_9_20_1","unstructured":"European Medicine Agency.COVID\u201019 vaccine safety update \u2010 VAXZEVRIA AstraZeneca;2021.https:\/\/www.ema.europa.eu\/en\/documents\/covid\u201019\u2010vaccine\u2010safety\u2010update\/covid\u201019\u2010vaccine\u2010safetyupdate\u2010vaxzevria\u2010previously\u2010covid\u201019\u2010vaccine\u2010astrazeneca\u20108\u2010september\u20102021_en.pdf. 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