{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:54:34Z","timestamp":1777600474631,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["202747\/Z\/16\/Z"],"award-info":[{"award-number":["202747\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Small fiber neuropathy usually presents with gradual and progressive chronic length\u2010dependent pain. Acute small fiber neuropathy is rarely reported. Three patients with acute onset neuropathic pain after Oxford\u2010AstraZeneca ChAdOx1\u2010S vaccination are described. Two patients were identified at the Oxford University NHS Foundation Trust, Oxford, UK and one patient in Red de Salud UC Christus, Santiago, Chile. All patients underwent a clinical assessment that included a detailed neurological examination, laboratory investigations, nerve conduction studies, thermal threshold testing, and skin biopsy for intra\u2010epidermal nerve fiber density. Patients seen in Oxford underwent MRI of the brain and spinal cord. Cerebrospinal analysis was not performed. Neuropathic symptoms (burning pain, dysaesthesias) developed in the hands and feet within 2\u2009weeks of vaccination. On clinical examination, there was pinprick and thermal hyposensitivity in the area of neuropathic pain. Laboratory investigation, nerve conduction tests, sympathetic skin responses, and MRI showed no relevant abnormalities. Thermal thresholds were abnormal and intra\u2010epidermal nerve fiber density in the lower leg was reduced. In two cases symptoms persist after several months. Three cases of definite acute small fiber neuropathy after Oxford\u2010AstraZeneca ChAdOx1\u2010S vaccination are described. At follow up, neuropathic pain was present in two of the patients.<\/jats:p>","DOI":"10.1111\/jns.12509","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T09:02:12Z","timestamp":1660381332000},"page":"325-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Acute small fiber neuropathy after <scp>Oxford\u2010AstraZeneca ChAdOx1\u2010S<\/scp> vaccination: A report of three cases and review of the literature"],"prefix":"10.1111","volume":"27","author":[{"given":"Molly G.","family":"Abbott","sequence":"first","affiliation":[{"name":"Medical Sciences Division University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Allawi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Hofer","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Ansorge","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefen","family":"Brady","sequence":"additional","affiliation":[{"name":"Oxford Muscle Service, Department of Neurology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7050-5133","authenticated-orcid":false,"given":"Ricardo","family":"Fadic","sequence":"additional","affiliation":[{"name":"Department of Neurology Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Torres","sequence":"additional","affiliation":[{"name":"Physiology Department Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Millennium Nucleus for the Study of Pain (MiNuSPain)  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-9189","authenticated-orcid":false,"given":"Margarita","family":"Calvo","sequence":"additional","affiliation":[{"name":"Physiology Department Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Millennium Nucleus for the Study of Pain (MiNuSPain)  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L. H.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-1543","authenticated-orcid":false,"given":"Andreas C.","family":"Themistocleous","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz333"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2006.00062.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000130"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577691"},{"key":"e_1_2_8_6_1","first-page":"540","article-title":"Acute small fibre sensory neuropathy: another variant of Guillain\u2010Barr\u00e9 syndrome?","volume":"72","author":"Seneviratne U","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.09.077"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27251"},{"issue":"903","key":"e_1_2_8_9_1","first-page":"e944","article-title":"European Federation of Neurological Societies\/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society","volume":"17","author":"Lauria G","year":"2010","journal-title":"Eur J Neurol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00271.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12842"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27458"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001146"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01556-7"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12509","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jns.12509","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:39:09Z","timestamp":1692614349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/jns.12509"],"URL":"https:\/\/doi.org\/10.1111\/jns.12509","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"2022-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}