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By immunohistochemistry and assessment of nerve fiber density, three models of induced hepatic regeneration were examined: the carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) intoxication, with two treatment periods of 14\u2009weeks and 18\u2009weeks; the partial hepatectomy (PH); the thyroid hormone (T3) treatment. TH\u2010 and ChAT\u2010LI nerve fibers were detectable mostly in the portal spaces, the TH\u2010LI ones occurring only around blood vessels while the ChAT\u2010LI nerve fibers were also associated with secretory ducts. The density of TH\u2010like immunoreactivity in the portal areas decreased after the CCl<jats:sub>4<\/jats:sub> 14\u2009weeks treatment and PH and increased after T3. By contrast, ChAT\u2010LI nerve fibers appeared particularly abundant around the neoductal elements in the CCl<jats:sub>4<\/jats:sub> rats and were rare to absent in the PH and T3\u2010treated groups. The ChAT\u2010LI nerve fiber density within the portal areas revealed an increase in the CCl<jats:sub>4<\/jats:sub>\u2010treated rats while showing no change in the PH and T3\u2010treated rats. The changes in the density of perivascular TH\u2010 and ChAT\u2010containing nerve fibers suggest a finely tuned autonomic modulation of hepatic blood flow depending on the type of subacute\/chronic induced hyperplasia, while the characteristic occurrence of the periductal cholinergic innervation after the CCl<jats:sub>4<\/jats:sub> treatment implies a selective parasympathetic role in regulating the physiopathological regenerative potential of the rat liver.<\/jats:p>","DOI":"10.1111\/jns.12521","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T04:50:21Z","timestamp":1668315021000},"page":"98-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The density of hepatic autonomic innervation differs between compensatory and direct hyperplasia rat 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