{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:47:20Z","timestamp":1788850040053,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T00:00:00Z","timestamp":1673654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019573","name":"Amsterdam University Medical Centers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OR18\u201015"],"award-info":[{"award-number":["W.OR18\u201015"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tremor in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is common, often unresponsive to treatment, and may contribute to disability. We aim to investigate whether tremor is associated with disability as measured in daily practice and clinical trials, independent of other impairments. We included 76 CIDP patients in this cross\u2010sectional study. We assessed tremor with the Tremor Research Group essential tremor rating assessment scale (TETRAS) and the Fahn\u2013Tolosa\u2013Marin clinical rating scale (FTM). Disability was measured with the inflammatory Rasch\u2010built overall disability scale (I\u2010RODS) and the adjusted Inflammatory Neuropathy Cause and Treatment disability scale (INCAT\u2010DS, categorized separately in arm score, or total score). Impairments including strength, sensory impairment, and fatigue were measured using specific impairment scales. We tested whether \u201cthe presence of a clinically relevant tremor\u201d (based on TETRAS and FTM) or \u201ctremor severity\u201d (FTM part B sum score) was associated with disability scores (I\u2010RODS, INCAT\u2010DS total score, and INCAT\u2010DS arm score), independent of the impairment scores, using multivariate regression. Both \u201cthe presence of a clinically relevant tremor\u201d and \u201ctremor severity\u201d were significantly associated with disability measured by the INCAT\u2010DS (arm score and total score), but not the I\u2010RODS, independent of strength, sensory impairment, and fatigue. The explained variances were low. Clinically relevant tremor can (partly) explain disability in CIDP, as measured with the INCAT\u2010DS, independent of muscle strength, sensory deficits, and fatigue. To assess disease activity in CIDP patients with tremor, both impairment and disability outcomes should be assessed, as disability is caused partly by tremor while the effect of immunotherapy on tremor seems limited.<\/jats:p>","DOI":"10.1111\/jns.12528","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T13:54:38Z","timestamp":1672062878000},"page":"58-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of tremor on disability assessment in chronic inflammatory demyelinating polyradiculoneuropathy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-4930","authenticated-orcid":false,"given":"R.","family":"van Veen","sequence":"first","affiliation":[{"name":"Department of Neurology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience, Neuroinfection and inflammation  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-5110","authenticated-orcid":false,"given":"G.","family":"Pallada","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience, Neuroinfection and inflammation  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-4081","authenticated-orcid":false,"given":"L.","family":"Wieske","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience, Neuroinfection and inflammation  Amsterdam The Netherlands"},{"name":"Department of Clinical Neurophysiology St. Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-1166","authenticated-orcid":false,"given":"S. E. M.","family":"Ten Holter","sequence":"additional","affiliation":[{"name":"Department of Neurology Catharina Hospital Eindhoven  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-9098","authenticated-orcid":false,"given":"A. F.","family":"van Rootselaar","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience, Neurodegeneration  Amsterdam The Netherlands"},{"name":"Department of Neurology Catharina Hospital Eindhoven  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-574X","authenticated-orcid":false,"given":"C.","family":"Verhamme","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience, Neuroinfection and inflammation  Amsterdam The Netherlands"},{"name":"Department of Clinical Neurophysiology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-0784","authenticated-orcid":false,"given":"R. 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