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This study aims to investigate the serum prevalence of similar antibodies in cats clinically diagnosed with immune\u2010mediated polyneuropathies. The sera from 41 cats clinically diagnosed with immune\u2010mediated polyneuropathies (IPN), 9 cats with other neurological or neuromuscular disorders (ONM) and 46 neurologically normal cats (CTRL) were examined for the presence of IgG antibodies against glycolipids GM1, GM2, GD1a, GD1b, GalNAc\u2010GD1a, GA1, SGPG, LM1, galactocerebroside and sulphatide. A total of 29\/41 IPN\u2010cats had either anti\u2010GM2 or anti\u2010GalNAc\u2010GD1a IgG antibodies, with 24\/29 cats having both. Direct comparison of anti\u2010GM2 (sensitivity: 70.7%; specificity: 78.2%) and anti\u2010GalNAc\u2010GD1a (sensitivity: 70.7%; specificity: 70.9%) antibodies narrowly showed anti\u2010GM2 IgG antibodies to be the better marker for identifying IPN\u2010cats when compared to the combined ONM and CTRL groups (<jats:italic>P<\/jats:italic>\u00a0=\u2009.049). Anti\u2010GA1 and\/or anti\u2010sulphatide IgG antibodies were ubiquitously present across all sample groups, whereas antibodies against GM1, GD1a, GD1b, SGPG, LM1 and galactocerebroside were overall only rarely observed. Anti\u2010GM2 and anti\u2010GalNAc\u2010GD1a IgG antibodies may serve as serum biomarkers for immune\u2010mediated polyneuropathies in cats, as previously observed in dogs and humans.<\/jats:p>","DOI":"10.1111\/jns.12529","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T13:39:12Z","timestamp":1672148352000},"page":"32-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum <scp>anti\u2010GM2<\/scp> and <scp>anti\u2010GalNAc\u2010GD1a<\/scp> ganglioside <scp>IgG<\/scp> antibodies are biomarkers for immune\u2010mediated polyneuropathies in cats"],"prefix":"10.1111","volume":"28","author":[{"given":"Susan K.","family":"Halstead","sequence":"first","affiliation":[{"name":"Neuroimmunology Laboratories, School of Infection and Immunity University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3843-2995","authenticated-orcid":false,"given":"Mark","family":"Jackson","sequence":"additional","affiliation":[{"name":"School of Cancer Sciences University of Glasgow  Bearsden UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rupp","sequence":"additional","affiliation":[{"name":"Tierklinik Hofheim  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Granger","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals, Royal Veterinary College University of London  Hatfield UK"},{"name":"CVS Referrals Bristol Veterinary Specialists  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Menchetti","sequence":"additional","affiliation":[{"name":"Neurology and Neurosurgery Division San Marco Veterinary Clinic and Laboratory  Veggiano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Galli","sequence":"additional","affiliation":[{"name":"Neurology and Neurosurgery Division San Marco Veterinary Clinic and Laboratory  Veggiano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Freeman","sequence":"additional","affiliation":[{"name":"Queens Veterinary School Hospital, Dept of Veterinary Medicine University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-8207","authenticated-orcid":false,"given":"Adriana","family":"Kaczmarska","sequence":"additional","affiliation":[{"name":"Small Animal Hospital, School of Biodiversity, One Health and Veterinary Medicine University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-8348","authenticated-orcid":false,"given":"Sofie F. 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