{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:15:10Z","timestamp":1790810110292,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013560","name":"GBS\/CIDP Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>International consensus on IgM\u2009\u00b1\u2009anti\u2010MAG\u2009\u00b1\u2009PNP (IgM PNP) is lacking. Despite increasing interest in clinical trials, validated disease\u2010specific measures are needed to adequately capture limitations and changes over time. The IMAGiNe (IgM\u2009\u00b1\u2009anti\u2010myelin associated glycoprotein [MAG] peripheral neuropathy) study surges as an international collaboration to create a standardized registry of patients with IgM\u2009\u00b1\u2009anti\u2010MAG PNP. The consortium, which currently consists of 11 institutions from 7 countries, presents here the IMAGiNe study design and protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Functional outcome measures will be constructed at the level of impairment, as well as activity and participation. We aim to describe the natural history of the cohort, the role of anti\u2010MAG antibodies, the presence of clinical subtypes, and potential biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The IMAGiNe study is a prospective, observational cohort study with a 3\u2010year follow\u2010up. At each assessment, researchers collect clinical data and subjects complete a list of preselected outcome measures. Among these, the \u201cPre\u2010Rasch\u2010built Overall Disability Scale (Pre\u2010RODS)\u201d questionnaire will be submitted to Rasch analysis to assess classic and modern clinimetric requirements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final measures will include the IgM\u2010PNP\u2010specific RODS and Ataxia Rating Scale (IgM\u2010PNP\u2010ARS). Descriptions of the disease course, clinical heterogeneity, treatment regimes, variations in laboratory values, and antibody titers will help reach consensus on diagnosis and follow\u2010up strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The constructed interval scales will be cross\u2010culturally valid and suitable for use in future clinical trials and daily practice. The ultimate goals are to improve functional individualized assessment, reach international consensus, and lay the foundations for successful designs in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12547","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T05:11:48Z","timestamp":1681276308000},"page":"269-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp>IgM<\/scp> anti\u2010<scp>MAG<\/scp><sup>\u00b1<\/sup> peripheral neuropathy (<scp>IMAGiNe<\/scp>) study protocol: An international, observational, prospective registry of patients with <scp>IgM<\/scp> M\u2010protein peripheral neuropathies"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-8218","authenticated-orcid":false,"given":"Tatiana","family":"Hamadeh","sequence":"first","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-0288","authenticated-orcid":false,"given":"Perry T. C.","family":"van Doormaal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Department of Neurology Tergooi Medical Center  Hilversum The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00eblle H. J.","family":"Pruppers","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes P. M.","family":"van de Mortel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke G. J.","family":"Hoeijmakers","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Cornblath","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander F. J. E.","family":"Vrancken","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina G.","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette C.","family":"Notermans","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar S. J.","family":"Merkies","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Department of Neurology Curacao Medical Center  Willemstad Cura\u00e7ao"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the IMAGiNe Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577725"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11139-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12342"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-9491-7.50103-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319857"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-016-0532-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000245368.36576.0d"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00283.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.3.615"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199908)22:8<1030::AID-MUS4>3.0.CO;2-H"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360313"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913129709016367"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000975"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000201193.00382.b3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00278.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12018"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285617746640"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9081-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.5.949"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.6.1385"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.4.710"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2016.1191013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.06.006"},{"issue":"5","key":"e_1_2_7_25_1","first-page":"CD002827","article-title":"Immunotherapy for IgM anti\u2010myelin\u2010associated glycoprotein paraprotein\u2010associated peripheral neuropathies","volume":"5","author":"Lunn MP","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"e_1_2_7_26_1","first-page":"CD002827","article-title":"Immunotherapy for IgM anti\u2010myelin\u2010associated glycoprotein paraprotein\u2010associated peripheral neuropathies","volume":"10","author":"Lunn MP","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400516"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.2.279"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000236"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.01.012"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306958"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.08.001"},{"key":"e_1_2_7_33_1","volume-title":"Probabilistic Models for some Intelligence and Attainment Tests","author":"Rasch G","year":"1960"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23108"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370705"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200001)23:1<73::AID-MUS9>3.0.CO;2-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-020-00064-2"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05583-7"},{"key":"e_1_2_7_39_1","first-page":"328","article-title":"Sample size and item calibration stability","volume":"7","author":"Linacre JM","year":"1994","journal-title":"Rasch Measur Transac"},{"issue":"1","key":"e_1_2_7_40_1","first-page":"905","article-title":"Rack and stack: time 1 vs. time 2 or pre\u2010test vs","volume":"17","author":"Wright BD","year":"2003","journal-title":"Post\u2010Test Rasch Measur Transac"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr318"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22681"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219042.60538.92"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318208824b"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.07.031"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12127"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9406(05)61264-3"},{"key":"e_1_2_7_50_1","first-page":"238","volume":"6","author":"Fisher WJ","year":"1992","journal-title":"Rasch Measur Transac"},{"issue":"5","key":"e_1_2_7_51_1","first-page":"753","article-title":"A methodological framework to develop and select indices for clinical trials: statistical and judgmental approaches","volume":"9","author":"Bombardier C","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_7_52_1","volume-title":"Health Measurement Scales: a Practical Guide to their Development and Use","author":"Streiner DL","year":"1998"},{"key":"e_1_2_7_53_1","volume-title":"Disability and Health: ICF","author":"World Health Organization International Classification of Functioning","year":"2001"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199231881.001.0001"},{"key":"e_1_2_7_55_1","first-page":"1","volume-title":"Rasch Models for Measurement: RUMM2030","author":"Andrich D","year":"2009"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001044"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13120"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T16:30:21Z","timestamp":1692549021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,20]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/jns.12547"],"URL":"https:\/\/doi.org\/10.1111\/jns.12547","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,20]]},"assertion":[{"value":"2023-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}