{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:11:29Z","timestamp":1792069889852,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>Charcot\u2013Marie\u2013Tooth Disease type 1A (CMT1A), the most common inherited peripheral neuropathy, is characterized by progressive sensory loss and weakness, which results in impaired mobility. Increased understanding of the genetics and pathophysiology of CMT1A has led to development of potential therapeutic agents, necessitating clinical trial readiness. Wearable sensors may provide useful outcome measures for future trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Individuals with CMT1A and unaffected controls were recruited for this 12\u2010month study. Participants wore sensors for in\u2010clinic assessments and at\u2010home, from which activity, gait, and balance metrics were derived. Mann\u2013Whitney U tests were used to analyze group differences for activity, gait, and balance parameters. Test\u2013retest reliability of gait and balance parameters and correlations of these parameters with clinical outcome assessments (COAs) were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty individuals, 15 CMT1A, and 15 controls, participated. Gait and balance metrics demonstrated moderate to excellent reliability. CMT1A participants had longer step durations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), shorter step lengths (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.03), slower gait speeds (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and greater postural sway (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) than healthy controls. Moderate correlations were found between CMT\u2010Functional Outcome Measure and step length (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.59;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02), and gait speed (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01); 11 out of 15 CMT1A participants demonstrated significant increases in stride duration between the first and last quarter of the 6\u2010min walk test, suggesting fatigue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In this initial study, gait and balance metrics derived from wearable sensors were reliable and associated with COAs in individuals with CMT1A. Larger longitudinal studies are needed to confirm our findings and evaluate sensitivity and utility of these disease\u2010specific algorithms for clinical trial use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.12562","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T13:49:23Z","timestamp":1684590563000},"page":"368-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Disease\u2010specific wearable sensor algorithms for profiling activity, gait, and balance in individuals with\n                    <scp>Charcot\u2013Marie\u2013Tooth<\/scp>\n                    disease type\n                    <scp>1A<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-6079","authenticated-orcid":false,"given":"K.","family":"Dinesh","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Sowden","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Behrens\u2010Spraggins","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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