{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:11:17Z","timestamp":1781662277221,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is a rare, acute neuropathy characterized by ascending muscle weakness. Age, axonal GBS variants, and antecedent <jats:italic>Campylobacter jejuni<\/jats:italic> infection are associated with severe GBS, but the detailed mechanisms of nerve damage are only partly explored. Pro\u2010inflammatory myeloid cells express NADPH oxidases (NOX) that generate tissue\u2010toxic reactive oxygen species (ROS) that are implicated in neurodegenerative diseases. This study analyzed the impact of variants of the gene encoding the functional NOX subunit CYBA (p22<jats:sup>phox<\/jats:sup>) on acute severity, axonal damage, and recovery in adult GBS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Extracted DNA from 121 patients was genotyped for allelic variation at rs1049254 and rs4673 within <jats:italic>CYBA<\/jats:italic> using real\u2010time quantitative polymerase chain reaction. Serum neurofilament light chain was quantified by single molecule array. Patients were followed for severity and motor function recovery for up to 13\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>CYBA<\/jats:italic> genotypes linked to reduced formation of ROS, i.e. rs1049254\/<jats:bold>G<\/jats:bold> and rs4673\/<jats:bold>A<\/jats:bold>, were significantly associated with unassisted ventilation, shorter time to normalization of serum neurofilament light chain and shorter time to regained motor function. Residual disability at follow\u2010up was confined to patients carrying <jats:italic>CYBA<\/jats:italic> alleles associated with high formation of ROS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>These findings implicate NOX\u2010derived ROS in GBS pathophysiology and <jats:italic>CYBA<\/jats:italic> alleles as biomarkers of severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12571","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T11:34:21Z","timestamp":1686224061000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp><i>CYBA<\/i><\/scp> allelic variants are associated with severity and recovery in <scp>Guillain\u2013Barr\u00e9<\/scp> syndrome"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0769-2815","authenticated-orcid":false,"given":"Andreas","family":"T\u00f6rnell","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Lagerstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mossberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Capio Neuro Center Carlanderska Hospital  Gothenburg 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