{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:27:14Z","timestamp":1783470434531,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Imbalance is a prominent symptom of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Although upper limb tremor in CIDP is described, lower limb tremor has not been assessed. The aim of this study was to determine whether lower limb tremor was present in CIDP and assess potential relationships with imbalance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional observational study of prospectively recruited consecutive patients with typical CIDP (<jats:italic>N<\/jats:italic>\u2009=\u200925). Clinical phenotyping, lower limb nerve conduction and tremor studies, and posturography analyses were performed. The Berg Balance Scale (BBS) divided CIDP patients into those with \u201cgood\u201d and \u201cpoor\u201d balance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower limb tremor was evident in 32% of CIDP patients and associated with poor balance (BBS<jats:sub>Tremor<\/jats:sub> 35 [23\u201346], BBS<jats:sub>No Tremor<\/jats:sub> 52 [44\u201355], <jats:italic>p<\/jats:italic>\u2009=\u2009.035). Tremor frequency was 10.2\u201312.5\u2009Hz with legs outstretched and on standing, apart from four patients with a lower frequency tremor (3.8\u20134.6\u2009Hz) while standing. Posturography analysis revealed a high\u2010frequency spectral peak in the vertical axis in 44% of CIDP patients (16.0\u2009\u00b1\u20090.4\u2009Hz). This was more likely in those with \u201cgood\u201d balance (40% vs. 4%, <jats:italic>p<\/jats:italic>\u2009=\u2009.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Lower limb tremor is present in one third of CIDP patients and is associated with poor balance. A high\u2010frequency peak on posturography is associated with better balance in CIDP. Lower limb tremor and posturography assessments could serve as important biomarkers of balance in a clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12574","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T12:55:15Z","timestamp":1686747315000},"page":"415-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Imbalance and lower limb tremor in chronic inflammatory demyelinating polyradiculoneuropathy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7249-210X","authenticated-orcid":false,"given":"Matthew","family":"Silsby","sequence":"first","affiliation":[{"name":"Neurology Department, Westmead Hospital Sydney &amp; Sydney Medical School University of Sydney  Sydney NSW Australia"},{"name":"Brain and Nerve Research Centre, Concord Hospital University of Sydney  Sydney Australia"},{"name":"Neurology Department Concord Hospital Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Yiannikas","sequence":"additional","affiliation":[{"name":"Neurology Department Concord Hospital Sydney  Sydney Australia"},{"name":"Neurology Department, Royal North Shore Hospital Sydney &amp; Sydney Medical School University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro F.","family":"Fois","sequence":"additional","affiliation":[{"name":"Neurology Department, Westmead Hospital Sydney &amp; Sydney Medical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Ng","sequence":"additional","affiliation":[{"name":"Neurology Department, Royal North Shore Hospital Sydney &amp; Sydney Medical School University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre University of Sydney &amp; Neurology Department, Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor S. 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