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Compared with other groups, ATTRwt patients had 10 letters lower visual acuity and a higher prevalence of glaucoma, cataract, and retinal pigment epithelium alterations. In the whole group of patients, especially in ATTRwt, we observed (1) a reduced corneal nerve fiber length and more tortuous stromal nerves at CCM, (2) a reduced macular volume and peripapillary nerve fiber layer thickness at OCT, and (3) impairment of peripapillary and macular vascularization at OCTA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Ophthalmological abnormalities are common in ATTRwt, significantly impairing visual acuity. Noninvasive imaging modalities allow for the identification of small nerve fibers and small vessel damage, which may represent further warning signs for early diagnosis of ATTRwt.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12589","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T16:09:37Z","timestamp":1691510977000},"page":"586-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ophthalmological involvement in wild\u2010type transthyretin amyloidosis: A multimodal imaging study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1749-2737","authenticated-orcid":false,"given":"Luisa","family":"Frizziero","sequence":"first","affiliation":[{"name":"Department of Neuroscience\u2014Ophthalmology Unit University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Salvalaggio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience\u2014Neurology Unit University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Cosmo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience\u2014Ophthalmology Unit University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Thoraco\u2010Vascular Sciences and Public Health, Cardiology Unit University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3132-6233","authenticated-orcid":false,"given":"Edoardo","family":"Midena","sequence":"additional","affiliation":[{"name":"Department of Neuroscience\u2014Ophthalmology Unit University of Padova  Padova Italy"},{"name":"IRCCS\u2212Fondazione Bietti  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-0200","authenticated-orcid":false,"given":"Chiara","family":"Briani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience\u2014Neurology Unit University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01274-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2021.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2019.1666413"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060927"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006075"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.1.123"},{"key":"e_1_2_9_8_1","unstructured":"Ruiz\u2010MedranoJ MariluzP ElenaA\u2010A et al.Involvement secondary to amyloidosis: from heart to eyes. 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