{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:50:35Z","timestamp":1791834635811,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1G1A1008446"],"award-info":[{"award-number":["2020R1G1A1008446"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Scrub typhus is an endemic disease in the fall season that occurs in a limited number of places known as the Tsutsugamushi Triangle. Peripheral neuropathy is a common complication of scrub typhus. Herein, we encountered several patients with ascending paralysis after scrub typhus infection, who were diagnosed with Guillain\u2010Barr\u00e9 syndrome (GBS). We aimed to investigate the clinical and laboratory characteristics of patients who developed GBS after scrub typhus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were retrospectively recruited from six nationwide tertiary centers in South Korea from January 2017 to December 2021. Patients who had been clinically diagnosed with GBS and confirmed to have scrub typhus via laboratory examination and\/or the presence of an eschar before the onset of acute limb paralysis were included. The GBS\u2010associated clinical and electrophysiological characteristics, outcomes, and scrub typhus\u2010associated features were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the seven enrolled patients, six were female and one was male. The median time from scrub typhus infection to the onset of limb weakness was 6 (range: 2\u201314) days. All patients had eschar on their bodies. Four patients (57.1%) were admitted to the intensive care unit and received artificial ventilation for respiratory distress. At 6\u2009months, the median GBS disability score was 2 (range, 1\u20134) points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Patients with scrub typhus\u2010associated GBS have a severe clinical presentation and require intensive treatment with additional immunotherapies. Therefore, GBS should be included in the differential diagnosis when peripheral neuropathies develop during scrub typhus treatment. Notably, scrub typhus is associated to GBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12614","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T22:49:56Z","timestamp":1706568596000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and laboratory findings in scrub typhus associated Guillain\u2010Barr\u00e9 syndrome in South Korea"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-3551","authenticated-orcid":false,"given":"Byeol\u2010A","family":"Yoon","sequence":"first","affiliation":[{"name":"Peripheral Neuropathy Research Center Dong\u2010A University College of Medicine  Busan South Korea"},{"name":"Department of Neurology Dong\u2010A University Medical Center  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-6147","authenticated-orcid":false,"given":"Sun\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-375X","authenticated-orcid":false,"given":"Juhyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Gyeongsang National University Hospital  Jinju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-9093","authenticated-orcid":false,"given":"Jung Im","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine Catholic University of Daegu  Daegu South 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University Medical Center  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-2135","authenticated-orcid":false,"given":"Seong\u2010il","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyung Hee University Hospital  Seoul South 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