{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:36:34Z","timestamp":1793864194899,"version":"4.6.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T00:00:00Z","timestamp":1707004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00283"],"award-info":[{"award-number":["PI20\/00283"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the incidence and risk factors for developing chemotherapy\u2010induced neuropathic pain (CINP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, file\u2010based analysis on cancer patients who received any type of conventional chemotherapy and for whom neurological evaluation was asked to reveal the extent of chemotherapy\u2010induced peripheral neurotoxicity (CIPN) with or without CINP. CINP was assessed by means of the PI\u2010NRS and Douleur Neuropathique\u20104 questionnaire. The total neuropathy score\u2010clinical version graded the severity of CIPN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The medical files of 500 chemotherapy\u2010treated cancer patients were reviewed. Any grade chronic CIPN was disclosed in 343 (68.6%) patients and CINP in 127 (37%) of them, corresponding to an overall percentage of 25.4% among all 500 included patients. The logistic regression analysis identified as independent predictors for CINP development the presence of uncomplicated diabetes (OR: 2.17; <jats:italic>p<\/jats:italic>\u2009=\u2009.039) and grade 2\u20133 chronic CIPN (OR: 1.61; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) as also the administration of combined paclitaxel plus cisplatin (reference variable), compared to oxaliplatin (OR: 0.18; <jats:italic>p<\/jats:italic>\u2009=\u2009.001) and taxanes (OR: 0.16; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The increased severity of acute OXAIPN was associated with CINP (OR: 4.51; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). OXA\u2010treated patients with persistent CINP presented a worst likelihood to improve after chemotherapy discontinuation, than patients receiving combined paclitaxel plus cisplatin (OR: 50; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of CINP in our cohort was comparable to previous reports, with severities fluctuating upwards during chemotherapy and declined post\u2010chemotherapy. Uncomplicated diabetes, the combined paclitaxel plus cisplatin treatment and the increased severity of acute oxaliplatin neurotoxicity mostly increase the risk for developing CINP. OXA\u2010treated patients present less possibilities to recover from CINP after chemotherapy discontinuation, than other chemotherapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12616","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:48:35Z","timestamp":1707094115000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Incidence and risk factors for developing chemotherapy\u2010induced neuropathic pain in 500 cancer patients: A file\u2010based observational study"],"prefix":"10.1111","volume":"29","author":[{"given":"Andreas A.","family":"Argyriou","sequence":"first","affiliation":[{"name":"Neurological Department \u201cAgios Andreas\u201d General Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6895-5047","authenticated-orcid":false,"given":"Jordi","family":"Bruna","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit Hospital Universitari de Bellvitge\u2010ICO L'Hospitalet, IDIBELL  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Kalofonou","sequence":"additional","affiliation":[{"name":"Department of Oncology Guy's and St. Thomas' NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Velasco","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit Hospital Universitari de Bellvitge\u2010ICO L'Hospitalet, IDIBELL  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelis","family":"Litsardopoulos","sequence":"additional","affiliation":[{"name":"Neurological Department \u201cAgios Andreas\u201d General Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse","family":"Alemany","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit Hospital Universitari de Bellvitge\u2010ICO L'Hospitalet, IDIBELL  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garifallia G.","family":"Anastopoulou","sequence":"additional","affiliation":[{"name":"Department of Medicine \u201cAgios Andreas\u201d General Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-778X","authenticated-orcid":false,"given":"Haralabos P.","family":"Kalofonos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology University Hospital of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8641-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-79090-7_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.01.018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2005.11.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.030"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-14-28"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.03.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1796639"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000969"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"S6","article-title":"Toxic neuropathy consortium of the peripheral nerve society. 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