{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:52:26Z","timestamp":1782604346188,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011724","name":"Muscular Dystrophy UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Histopathological diagnosis is the gold standard in many acquired inflammatory, infiltrative and amyloid based peripheral nerve diseases and a sensory nerve biopsy of sural or superficial peroneal nerve is favoured where a biopsy is deemed necessary. The ability to determine nerve pathology by high\u2010resolution imaging techniques resolving anatomy and imaging characteristics might improve diagnosis and obviate the need for biopsy in some. The sural nerve is anatomically variable and occasionally adjacent vessels can be sent for analysis in error. Knowing the exact position and relationships of the nerve prior to surgery could be clinically useful and thus reliably resolving nerve position has some utility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>7T images of eight healthy volunteers' (HV) right ankle were acquired in a pilot study using a double\u2010echo in steady\u2010state sequence for high\u2010resolution anatomy images. Magnetic Transfer Ratio images were acquired of the same area. Systematic scoring of the sural, tibial and deep peroneal nerve around the surgical landmark 7\u2009cm from the lateral malleolus was performed (number of fascicles, area in voxels and mm<jats:sup>2<\/jats:sup>, diameter and location relative to nearby vessels and muscles).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sural and tibial nerves were visualised in the high\u2010resolution double\u2010echo in steady\u2010state (DESS) image in all HV. The deep peroneal nerve was not always visualised at level of interest. The MTR values were tightly grouped except in the sural nerve where the nerve was not visualised in two HV. The sural nerve location was found to be variable (e.g., lateral or medial to, or crossing behind, or found positioned directly posterior to the saphenous vein).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>High\u2010resolution high\u2010field images have excellent visualisation of the sural nerve and would give surgeons prior knowledge of the position before surgery. Basic imaging characteristics of the sural nerve can be acquired, but more detailed imaging characteristics are not easily evaluable in the very small sural and further developments and specific studies are required for any diagnostic utility at 7T.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12645","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T09:50:10Z","timestamp":1721987410000},"page":"368-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Initial findings using high\u2010resolution magnetic resonance imaging for visualisation of the sural nerve and surrounding anatomy in healthy volunteers at <scp>7 Tesla<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-6191","authenticated-orcid":false,"given":"Amy R.","family":"McDowell","sequence":"first","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zambreanu","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"},{"name":"Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza A.","family":"Salhab","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-3573","authenticated-orcid":false,"given":"Carolynne M.","family":"Doherty","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Bridgen","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department School of Biomedical Engineering and Imaging Sciences, King's College London  London UK"},{"name":"London Collaborative Ultra High Field System (LoCUS) Kings College London  London UK"},{"name":"Guys and St Thomas' NHS Foundation Trust Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Lally","sequence":"additional","affiliation":[{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachit","family":"Shah","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"},{"name":"Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimu","family":"Huo","sequence":"additional","affiliation":[{"name":"Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Wastling","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Yousry","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"},{"name":"Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Morrow","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"},{"name":"Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Thornton","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"},{"name":"Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-6027","authenticated-orcid":false,"given":"Michael P.","family":"Lunn","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology  London UK"},{"name":"Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery  London UK"},{"name":"NIHR University College London Hospitals Biomedical Research Centre, Research &amp; Development  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20220336"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182904f3f"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2023.01.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.04.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.1286"},{"key":"e_1_2_7_7_1","unstructured":"Brain 2015 138"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27647"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.10016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26800"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20819"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26383"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26164"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T11:13:26Z","timestamp":1726830806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/jns.12645"],"URL":"https:\/\/doi.org\/10.1111\/jns.12645","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,26]]},"assertion":[{"value":"2023-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}