{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:12:25Z","timestamp":1788999145897,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Chemotherapy\u2010induced peripheral neurotoxicity (CIPN), with paraesthesia, numbness, dysesthesia and neuropathic pain ranks among the most common dose\u2010limiting toxicity of several widely used anticancer drugs. Recent studies revealed the microvascular angiogenesis as a new important actor, beside peripheral neurons, in the neurotoxicity and neuropathic pain development and chronicisation. The aim of this work is to elucidate the role of vascular alterations in CIPN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the severity of CIPN with neurophysiological, behavioural and neuropathological analysis together with the microvascular network in central and peripheral nervous systems of rats in order to correlate the features of the CIPN and the vascular abnormalities. The vascular network was quantitatively evaluated through synchrotron radiation\u2010based X\u2010ray phase\u2010contrast micro\u2010tomography imaging, measuring four specific parameters: vascular density, vessel diameter, vessel tortuosity and branching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rats exposed to paclitaxel and affected by a severe painful sensory axonopathy showed an increased vascular density (putative sprouting angiogenesis) in the crucial districts of the central (somatosensory cortex and lumbar spinal cord) and peripheral nervous system (lumbar dorsal root ganglia). In addition, the complexity of the vascular network and the size of neo\u2010formed vessels were significantly decreased in specific regions. On the other hand, less significant changes were observed in rats exposed to cisplatin, affected by a painless peripheral neuropathy, suggesting a specific involvement of neo\u2010angiogenesis in the development of severe neurotoxicity and neuropathic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretations<\/jats:title><jats:p>These new ground\u2010breaking results can shed light on new pathogenetic mechanisms and potential novel therapeutic approaches for painful\u2010CIPN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12660","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:30:35Z","timestamp":1729582235000},"page":"537-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Paclitaxel alters the microvascular network in the central and peripheral nervous system of rats with chemotherapy\u2010induced painful peripheral neuropathy"],"prefix":"10.1111","volume":"29","author":[{"given":"Antonio Giuliano","family":"Zippo","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, Consiglio Nazionale delle Ricerche  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Rodriguez\u2010Menendez","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Canta","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Chiorazzi","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ballarini","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Monza","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-6183","authenticated-orcid":false,"given":"Paola","family":"Alberti","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"},{"name":"Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-4577","authenticated-orcid":false,"given":"Cristina","family":"Meregalli","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bravin","sequence":"additional","affiliation":[{"name":"Physics Department University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Coan","sequence":"additional","affiliation":[{"name":"Faculty of Physics Ludwig\u2010Maximillian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Longo","sequence":"additional","affiliation":[{"name":"Elettra\u2010Sincrotrone Trieste S.C.p.A  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Saccomano","sequence":"additional","affiliation":[{"name":"Elettra\u2010Sincrotrone Trieste S.C.p.A  Trieste Italy"},{"name":"Department of Architecture and Engineering University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Paiva","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physics to Biomedical Science, Physics Institute Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Tromba","sequence":"additional","affiliation":[{"name":"Elettra\u2010Sincrotrone Trieste S.C.p.A  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-2406","authenticated-orcid":false,"given":"Guido","family":"Cavaletti","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"},{"name":"Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0963-7107","authenticated-orcid":false,"given":"Valentina Alda","family":"Carozzi","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery, University of Milano\u2010Bicocca  Milan Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000724"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440\u2010020\u201000109\u2010y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246088"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24951"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2010.02999.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz075"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136233"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708786848569"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics9100229"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010021\u201001142\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061451"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1796639"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.10.014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.038"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010021\u201001127\u20101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13654"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136087"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.626687"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135739"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010020\u201002755\u2010w"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.08.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8090324"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010021\u201002127\u2010x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11020093"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2020.103499"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.12.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170814"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116070"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603\u2010653"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04481"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2010.01.005"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ima.22520"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2021.109323"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2009.07.001"},{"issue":"6","key":"e_1_2_9_38_1","first-page":"883","article-title":"Cisplatin\u2010induced DNA\u2010platination in experimental dorsal root ganglia neuronopathy","volume":"20","author":"Meijer C","journal-title":"Neurotoxicology"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.09.029"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physo.2020.100050"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40679\u2010016\u20100036\u20108"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12609"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.07.022"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.12.003"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(81)90007-1"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199805)251:1<87::AID-AR14>3.0.CO;2-7"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm259"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088067"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","unstructured":"ZippoAG Del GrossoV PateraA et al.Chronic pain alters microvascular architectural organization of somatosensory cortex.2019. doi:10.1101\/755132","DOI":"10.1101\/755132"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5494"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109\u2010018\u20101707\u20109"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180586"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481\u2010014\u20109531\u20107"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19\u201014\u201005731.1999"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953\u2010816x.2000.01326.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101797.2007.00879_2.x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.88"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws145"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.12.003"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16244"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2828"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640\u2010022\u201000582\u20108"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.11.055"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.12.011"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.175976"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.470849"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300019"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201004\u20100934"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.012"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150124"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.2165\/11207720\u2010000000000\u201000000"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001000"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.12660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T05:50:29Z","timestamp":1733723429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.12660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/jns.12660"],"URL":"https:\/\/doi.org\/10.1111\/jns.12660","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"2024-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}