{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:03:24Z","timestamp":1788357804076,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is difficult to distinguish from mimicking disorders, with misdiagnosis resulting in IVIG overutilization. We evaluate a clinical\u2010electrophysiological model to facilitate CIDP versus mimic neuropathy prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the European Academy of Neurology\/Peripheral Nerve Society (EAN\/PNS) 2021 CIDP guidelines we derived 26 clinical and 144 nerve conduction variables. The model was generated and validated utilizing total CIDP (<jats:italic>n<\/jats:italic>\u2009=\u2009129) and mimics (<jats:italic>n<\/jats:italic>\u2009=\u2009309); including (1) IgG4\u2010nodopathies; (2) POEMS (polyneuropathy\u2013organomegaly\u2013endocrinopathy\u2013monoclonal protein\u2010skin changes); (3) anti\u2010myelin\u2010associated\u2010glycoprotein; (4) paraneoplastic; (5) Waldenstr\u00f6m B\u2010cell lymphoma; (6) diabetic neuropathies; (7) amyloidosis; (8) Charcot\u2013Marie\u2013Tooth; (9) motor neuropathies\/neuronopathies; and (10) idiopathic\u2010inflammatory\u2010myopathies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 9282 clinical and 51\u2009408 electrophysiological data points. Univariate analysis identified 11 of 26 clinical variables with significant odds ratios. A multivariate regression model using four clinical and two electrophysiologic variables achieved 93% area\u2010under\u2010curve (95% CI 91\u201395): progression over 8\u2009weeks (OR 40.66, 95% CI 5.31\u2013311.36), absent autonomic involvement (OR 17.82, 95% CI 2.93\u2013108.24), absent muscle atrophy (OR 16.65, 95% CI 3.27\u201384.73), proximal weakness (OR 3.63, 95% CI 1.58\u20138.33), ulnar motor conduction velocity slowing &lt;\u200935.7\u2009m\/s (OR 5.21, 95% CI 2.13\u201312.76), and ulnar motor conduction block (OR 13.37, 95% CI 2.47\u201372.40). A web\u2010based probability calculator (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/news.mayocliniclabs.com\/cidp-calculator\/\">https:\/\/news.mayocliniclabs.com\/cidp\u2010calculator\/<\/jats:ext-link>) was developed, with 100% sensitivity and 68% specificity at a 92% probability threshold. Specificity improved to 93% when considering \u201cred flags,\u201d electrophysiologic criteria, and laboratory testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>A probability calculator using clinical electrophysiological variables assists CIDP differentiation from mimics, with scores below 92% unlikely to have CIDP. The highest specificity is achieved by considering clinical \u201cred flags,\u201d electrophysiologic demyelination, and laboratory testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12682","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:59:09Z","timestamp":1736751549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Distinguishing Chronic Inflammatory Demyelinating Polyneuropathy From Mimic Disorders: The Role of Statistical Modeling"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-7776","authenticated-orcid":false,"given":"Grace","family":"Swart","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5155-4371","authenticated-orcid":false,"given":"Michael P.","family":"Skolka","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahar","family":"Shelly","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Neurology Rambam Health Care Clinic  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars Sinai  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-2680","authenticated-orcid":false,"given":"Jeffrey A.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyanshu","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyv","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurology Cedars Sinai  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Spies","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruple S.","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smathorn","family":"Thakolwiboon","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R.","family":"Santilli","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebatallah","family":"Rashed","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igal","family":"Mirman","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Tennessee Medical Center  Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Swart","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Berini","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Shouman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus V.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Mauermann","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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