{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:27:18Z","timestamp":1789522038211,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>A recent study reported that Oropouche virus (OROV) infection may play a role in the etiology of Guillain\u2013Barr\u00e9 syndrome. We aimed to identify the neurological performance, disease\u2010modifying therapies, and clinical outcomes related to patients with Oropouche\u2010associated Guillain\u2013Barr\u00e9 syndrome admitted to the critical care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an analysis of 210 patients diagnosed with Guillain\u2013Barr\u00e9 syndrome and suspicion of Oropouche viral infection admitted to the critical care units from June 2024 to September 2024 using the national administrative healthcare data. OROV was identified by reverse\u2010transcriptase\u2013polymerase\u2010chain\u2010reaction. Patients with Guillain\u2013Barr\u00e9 syndrome and Oropouche infection were compared with those without Oropouche infection in terms of demography features, neurological performance, disease\u2010modifying therapies, and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients had a severe disease. Mechanical ventilation was required in 28.6%. Overall mortality rate was 14.3%. The median time from onset of weakness to intensive care unit discharge, and the median time from hospital admission to intensive care unit discharge was 18\u2009days (IQR: 13\u201324.3\u2009days) and 13\u2009days (IQR: 9\u201319\u2009days), respectively. Oropouche viral infection was detected in 43 (20.5%) patients. There were no differences among patients with and without Oropouche viral infection regarding general characteristics, neurological performance, disease\u2010modifying therapies, and outcomes. After adjusting for confounders in multivariate logistic regression analysis, Oropouche viral infection (OR: 1.94; 95% CI: 0.72\u20135.20; <jats:italic>p<\/jats:italic>\u2009=\u20090.189) was not related to increased mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Oropouche viral infection does not modify the clinical course, disease severity, and outcomes of patients with Guillain\u2013Barr\u00e9 syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.12683","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T04:54:33Z","timestamp":1737694473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neurological Performance and Clinical Outcomes Related to Patients With Oropouche\u2010Associated Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-5373","authenticated-orcid":false,"given":"Frank D.","family":"Martos\u2010Ben\u00edtez","sequence":"first","affiliation":[{"name":"Intensive Care Unit National Institute of Neurology and Neurosurgery  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliovanys","family":"Betancourt\u2010Plaza","sequence":"additional","affiliation":[{"name":"National Department of Urgency Emergency, and Transplant of the Ministry of Public Health  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isleidys","family":"Osorio\u2010Carmenates","sequence":"additional","affiliation":[{"name":"National Department of Urgency Emergency, and Transplant of the Ministry of Public Health  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadieska J.","family":"Gonz\u00e1lez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"National Directorate of Hospitals of the Ministry of Public Health of Cuba  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Mor\u00e1les\u2010Su\u00e1rez","sequence":"additional","affiliation":[{"name":"National Directorate of Science and Technological Innovation of the Ministry of Public Health  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carilda E.","family":"Pe\u00f1a\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Viceministry of Hygiene Epidemiology and Microbiology of the Ministry of Public Health  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudeily L.","family":"P\u00e9rez\u2010Matos","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Provincial Clinical Surgical Teaching Hospital \u201cFaustino P\u00e9rez\u201d  Matanzas Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zurina","family":"Lestayo\u2010O'Farrill","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Neurology and Neurosurgery  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"de Armas\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"National Department of Communicable Diseases of the Ministry of Public Health  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raysa C.","family":"C\u00e1rdenas\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Intensive Care Unit National Institute of Neurology and Neurosurgery  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judet","family":"Izquierdo\u2010Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Intensive Care Unit National Institute of Neurology and Neurosurgery  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto S\u00e1nchez\u2010de","family":"la Rosa","sequence":"additional","affiliation":[{"name":"Intensive Care Unit National Institute of Neurology and Neurosurgery  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Versis","family":"Orama\u2010Requejo","sequence":"additional","affiliation":[{"name":"Intermediate Care Unit Hospital of Palamos  Palamos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00516-4"},{"key":"e_1_2_8_3_1","article-title":"Re\u2010Emergence of Oropouche Virus Between 2023 and 2024 in Brazil: An Observational Epidemiological Study","author":"Scachetti G. 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