{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:42:11Z","timestamp":1790109731924,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Despite the known association of hip dysplasia and Charcot Marie Tooth disease (CMT), evidence is limited regarding its exact prevalence. Available studies pre\u2010date genetic confirmation of CMT subtypes and current hip reconstruction surgical options. This study examined the prevalence of hip dysplasia in CMT in a tertiary neuromuscular center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of children with CMT who had at least one pelvic radiograph between 2000 and 2020. Reimer's migration percentage, acetabular index and lateral center edge angle were used to identify hip dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 178 children were included with a median age of 6.4 (IQR 3.4\u201311.3) years at CMT diagnosis. First pelvic radiographs were performed at a median age of 8.0 (IQR 4.6\u201312.2) years and 64 (35.8%) had hip dysplasia, of which 20 normalized over time. Repeat radiographs were done in 96\/178 children (53.9%), and six children with originally normal radiographs developed later radiographic hip dysplasia. At the time of last follow up, 50\/178 children (28.1%) had hip dysplasia and 17\/178 children (9.6%) required surgical intervention. The frequency of hip dysplasia in specific CMT subtypes was: 28\/100 in CMT1A, 5\/7 in Dejerine\u2010Sottas disease, 3\/10 in CMT2A, and 4\/4 in <jats:italic>TRPV4<\/jats:italic>\u2010related CMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The prevalence of hip dysplasia in children with CMT in this cohort was estimated to be between 9.6% and 28.1%. Serial imaging is important to monitor outcomes into adulthood. Specific CMT subtypes were more likely to be associated with hip dysplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.70002","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T11:57:31Z","timestamp":1738324651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hip Dysplasia in Charcot\u2013Marie\u2013Tooth Disease: Insights From a Large Cohort of Children and Adolescents"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-762X","authenticated-orcid":false,"given":"Khian Aun","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Department of Pediatrics Hospital Sultanah Bahiyah  Alor Setar Kedah Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique 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