{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:02:19Z","timestamp":1789549339798,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess the impact of metabolic factors and comorbidities on peripheral neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Qatari nationals and long\u2010term residents from the Qatar Biobank underwent clinical\/metabolic assessments, including iDXA to measure visceral adipose tissue (VAT) and subcutaneous (SAT) volumes, inflammation, thyroid function, carotid intima media thickness (CIMT), corneal confocal microscopy (CCM), vibration perception threshold (VPT), and DN4 questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 332 adults aged 43.4\u2009\u00b1\u200912.7\u2009years, the prevalence of neuropathy was 3.9%. The prevalence of T2D was 16.6%, and the prevalence of neuropathy was significantly higher in T2D (14.5% vs. 1.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). A higher HbA1c (<jats:italic>p<\/jats:italic>\u2009=\u20090.05) and lower eGFR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were associated with reduced inferior whorl length (IWL) and lower FT3 was associated with reduced corneal nerve fiber length (CNFL) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Triglycerides were associated with increased neuropathic symptoms (<jats:italic>p<\/jats:italic>\u2009=\u20090.05). All the risk factors in this study contributed to 39% of neuropathy in T2D but had a minimal impact in those without T2D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the importance of additional risk factors beyond traditional risk factors associated with peripheral neuropathy in T2D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.70004","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T07:04:41Z","timestamp":1739603081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Differential Impact of Metabolic Factors and Comorbidities on Peripheral Neuropathy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-1248","authenticated-orcid":false,"given":"Georgios","family":"Ponirakis","sequence":"first","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis N.","family":"Petropoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidra","family":"Abdulshakoor","sequence":"additional","affiliation":[{"name":"Qatar Biobank for Medical Research Qatar Biobank, Qatar Foundation, Hamad Medical City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenneth M.","family":"Concepcion","sequence":"additional","affiliation":[{"name":"Qatar Biobank for Medical Research Qatar Biobank, Qatar Foundation, Hamad Medical City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara H.","family":"Khalfalla","sequence":"additional","affiliation":[{"name":"Qatar Biobank for Medical Research Qatar Biobank, Qatar Foundation, Hamad Medical City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iynas S. A.","family":"Elamin","sequence":"additional","affiliation":[{"name":"Qatar Biobank for Medical Research Qatar Biobank, Qatar Foundation, Hamad Medical City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer T. H.","family":"AlZawqari","sequence":"additional","affiliation":[{"name":"Qatar Biobank for Medical Research Qatar Biobank, Qatar Foundation, Hamad Medical City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einas","family":"Elgassim","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej","family":"Baraka","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aljazi M.","family":"Al\u2010Khalifa","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad R.","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa A.","family":"El Deeb","sequence":"additional","affiliation":[{"name":"Qatar Biobank for Medical Research Qatar Biobank, Qatar Foundation, Hamad Medical City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla","family":"Afifi","sequence":"additional","affiliation":[{"name":"Qatar Biobank for Medical Research Qatar Biobank, Qatar Foundation, Hamad Medical City  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-8903","authenticated-orcid":false,"given":"Rayaz A.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine\u2010Qatar, Qatar Foundation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0565"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16\u20102042"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047\u2010020\u201000383\u20102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2016.03.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13388"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20101842"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20100012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16\u20100081"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz058"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102022\u2010062188"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201009333\u20103"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13815"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15511"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102020\u2010001420"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021778"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP\u20102018\u20100459"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2023.126609"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/Dmso.S427510"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S337779"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2482453"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201040752\u2010y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100635\u20100826"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010021\u201000760\u20102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2024.108766"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoz029"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2307"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2023.2165811"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196631"},{"key":"e_1_2_9_30_1","unstructured":"Federation ID \u201cIDF Diabetes Atlas: Qatar \u201dhttps:\/\/diabetesatlas.org\/data\/en\/country\/161\/qa.html."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13388"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001916"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2022.04.006"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010099"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/ewjm.172.2.102"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16152496"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092358"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20102277"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.892648"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20100382"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.459"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20101819"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1393105"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10070493"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.70004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:57:57Z","timestamp":1743209877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.70004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jns.70004"],"URL":"https:\/\/doi.org\/10.1111\/jns.70004","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]},"assertion":[{"value":"2024-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70004"}}