{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:16:46Z","timestamp":1788675406718,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune\u2010mediated disorder; about 20%\u201330% of patients do not adequately respond to first\u2010line treatments (immunoglobulins, therapeutic plasmapheresis, and corticosteroids) posing diagnostic and therapeutic challenges.<\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n We report the case of a 58\u2010year\u2010old man diagnosed with CIDP. During follow\u2010up, he progressively became refractory to all first\u2010line treatments. Therefore, 20\u2009months after the diagnosis, an add\u2010on therapy with Rituximab was tried. Despite previous works supporting the use of Rituximab in refractory CIDP, in our case, the patient experienced relapses and progressive increases in disability. After the exclusion of potential CIDP mimics and considering the histological findings that showed complement activation, we opted for an innovative therapeutic approach with Eculizumab that granted a significant clinical and neurophysiological benefit that persists after 7\u2009months of follow\u2010up.<\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n CIDP pathogenesis is characterized by a complex interplay of different immunopathological mechanisms, and the complement system may play a major role. The present case supports the role of complement\u2010dependent toxicity in CIDP and suggests that complement\u2010targeted therapies may represent a well\u2010tolerated and effective alternative for CIDP treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jns.70010","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:24:44Z","timestamp":1741731884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eculizumab as a Disease\u2010Modifying Therapy in Chronic Inflammatory Demyelinating Polyneuropathy (\n CIDP<\/scp>\n ): A Case Report"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6546-5745","authenticated-orcid":false,"given":"Edoardo Dalmato","family":"Schilke","sequence":"first","affiliation":[{"name":"PhD Program in Neuroscience, School of Medicine and Surgery University of Milano\u2010Bicocca Milan Italy"},{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Cereda","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Fusco","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Stanzani","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Marzorati","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ripolone","sequence":"additional","affiliation":[{"name":"Neuromuscular and Rare Diseases Unit, Department of Neuroscience Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Bertolasi","sequence":"additional","affiliation":[{"name":"Neuromuscular and Rare Diseases Unit, Department of Neuroscience Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Frigo","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Molteni","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Valduce Hospital \u2010 Villa\u2010Beretta Costa Masnaga Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Farina","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Valduce Hospital \u2010 Villa\u2010Beretta Costa Masnaga Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ferrarese","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"},{"name":"School of Medicine and Surgery and Milan Centre for Neuroscience (NeuroMI), University of Milano\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-2406","authenticated-orcid":false,"given":"Guido","family":"Cavaletti","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"},{"name":"Experimental Neurology Unit School of Medicine and Surgery, University of Milano\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Balducci","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Foundation IRCCS San Gerardo Dei Tintori Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/JNS.12455"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117098"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S13311\u2010022\u201001221\u2010Y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/JNS.12646"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000204596"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T20:56:38Z","timestamp":1743195398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jns.70010"],"URL":"https:\/\/doi.org\/10.1111\/jns.70010","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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