{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:33:56Z","timestamp":1787376836497,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Domino liver transplantation (DLT) has been used to address the shortage of donor organs. However, recipients of liver grafts from patients with hereditary transthyretin amyloidosis (ATTRv) develop de novo transthyretin (TTR) amyloidosis. Our aim is to describe the clinical presentation of patients with acquired TTR amyloidosis and compare the rate of neuropathy progression (NP) with untreated ATTRv amyloidosis with neuropathy (ATTRv\u2010NP) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with acquired TTR amyloidosis after DLT followed at a reference centre were evaluated. Medical records were reviewed for clinical characterization and systematic assessment of neuropathy. NP was defined as an increase in neuropathy impairment score of the lower limbs (NIS\u2010LL) at 12\u2009months and compared to a historical control group of untreated ATTRv amyloidosis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients with acquired ATTR amyloidosis were included. Time from DLT to neuropathy onset was 9  2.0\u2009years and the majority of patients reported feet sensory changes as first symptom. Thirteen patients with \u2265\u20092 evaluations with 12\u2010months interval were analysed. Almost all patients developed a neuropathic phenotype with small nerve fibre involvement. Neuropathy progression was similar to untreated ATTRv\u2010NP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Recipients from liver grafts of ATTRv patients develop de novo amyloidosis with clinical presentation and NP similar to untreated ATTRv amyloidosis patients. Study of these patients might help elucidate the pathways for ATTR fibril formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.70016","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T01:24:34Z","timestamp":1744075474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuropathy Progression in Acquired Amyloidosis After Domino Liver Transplantation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-9787","authenticated-orcid":false,"given":"Catarina","family":"Falc\u00e3o de Campos","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital Santa Maria, ULS Santa Maria  Lisbon Portugal"},{"name":"Faculty of Medicine, Centro de Estudos Egas Moniz IMM\u2010JLA, University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital de Cascais Dr. Jos\u00e9 de Almeida  Cascais Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Santa Maria, ULS Santa Maria  Lisbon Portugal"},{"name":"Faculty of Medicine, Centro de Estudos Egas Moniz IMM\u2010JLA, University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Santa Maria, ULS Santa Maria  Lisbon Portugal"},{"name":"Faculty of Medicine, Centro de Estudos Egas Moniz IMM\u2010JLA, University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Oliveira Santos","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Santa Maria, ULS Santa Maria  Lisbon Portugal"},{"name":"Faculty of Medicine, Centro de Estudos Egas Moniz IMM\u2010JLA, University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Santa Maria, ULS Santa Maria  Lisbon Portugal"},{"name":"Faculty of Medicine, Centro de Estudos Egas Moniz IMM\u2010JLA, University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0210-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93127-M"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318248df18"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000574"},{"key":"e_1_2_7_6_1","unstructured":"\u201cThe Familial Amyloidotic Polyneuropathy World Transplant Registry: The Domino Liver Transplant Registry \u201d2021. 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