{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:36Z","timestamp":1787015496088,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["NPRP11S\u20100110\u2010180247"],"award-info":[{"award-number":["NPRP11S\u20100110\u2010180247"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperglycemia is a major driver of diabetic peripheral neuropathy (DPN) in type 1 diabetes mellitus (T1DM). Advanced hybrid closed\u2010loop (AHCL) technologies improve glycemic control and reduce glycemic variability and may improve DPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with T1DM treated for 9.8\u2009\u00b1\u20090.32\u2009months with the 780G SmartGuard system (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) were compared with patients with T1DM on MDI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). Time in range (TIR), time above range (TAR), time below range (TBR), glycemic variability, and HbA\n                      <jats:sub>1c<\/jats:sub>\n                      were evaluated, and corneal confocal microscopy (CCM) was undertaken to quantify corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL), and inferior whorl length (IWL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants using the 780G system had a significantly higher TIR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lower glycemic variability (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and less time in level 2 hyperglycemia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), level 1 hyperglycemia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and level 2 hypoglycemia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) compared with the MDI group. CNFD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), CNBD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), CNFL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and IWL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly higher in the 780G group compared with the MDI group and comparable to healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The MiniMed 780G with SmartGuard improves glycemic control and variability with an improvement in small nerve fiber morphology in patients with DPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70026","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:15:22Z","timestamp":1747210522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Advanced Hybrid Closed\u2010Loop Insulin Delivery Is Associated With Improved Glycemic Indicators and Normalization of Small Nerve Fibre Structure in Adults With Type 1 Diabetes"],"prefix":"10.1111","volume":"30","author":[{"given":"Hoda","family":"Gad","sequence":"first","affiliation":[{"name":"Medicine Department Weill Cornell Medicine\u2010Qatar  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einas","family":"Elgassim","sequence":"additional","affiliation":[{"name":"Medicine Department Weill Cornell Medicine\u2010Qatar  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kawsar Mohamed 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