{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:05:09Z","timestamp":1791975909948,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.TR22\u201001"],"award-info":[{"award-number":["W.TR22\u201001"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic itch, or pruritus, is a common discomfort of the skin. Chronic itch has been described as a symptom of small fiber neuropathy (SFN), a disorder affecting the small myelinated A\u03b4\u2010 and unmyelinated C\u2010fibers. While prior studies report itch rates in SFN ranging from 63%\u201368%, a distinct pattern has not been identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to describe the clinical characteristics of itch in a large cohort of SFN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between May 2016 and August 2022, 1415 patients filled out an exploratory questionnaire about characteristics of their itch symptoms. 83% were diagnosed with SFN based on the Besta criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Itch was reported in 66% of SFN patients, mainly experienced as tickling, prickling, and tingling sensations. Itch was most common in the evening, with 98% reporting continuous or episodic symptoms during this time. The itch was predominantly localized to the distal extremities, especially the lower legs and feet (over 50% of patients), with additional reports on the back (25%) and face (27%). Unlike the typical stocking\u2010glove distribution seen with neuropathic pain, itch showed a slightly more proximal locus. SFN patients were more likely to report itching in the hands and feet than non\u2010SFN patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This study reveals that itch in SFN is a frequent, heterogeneous symptom that may differ from neuropathic pain in its distribution. Itch, particularly in the hands and feet, may provide diagnostic guidance and suggest SFN as a potential diagnosis. This finding warrants further research on itch mechanisms and its diagnostic value in SFN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.70041","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T10:14:58Z","timestamp":1750846498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Where Does It All Itch? Exploring the Characteristics of Pruritus in Small Fiber Neuropathy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5385-7575","authenticated-orcid":false,"given":"Dennis","family":"Kool","sequence":"first","affiliation":[{"name":"Mental Health and Neuroscience Research Institute, Maastricht University  Maastricht the Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-0027","authenticated-orcid":false,"given":"Janneke G. J.","family":"Hoeijmakers","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute, Maastricht University  Maastricht the Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina G.","family":"Faber","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute, Maastricht University  Maastricht the Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center+  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar S. 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