{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:44:22Z","timestamp":1784360662953,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>IgM monoclonal gammopathy\u2010associated polyneuropathy with(out) anti\u2010myelin associated glycoprotein (\u00b1anti\u2010MAG) is a rare immune\u2010mediated disease that may cause severe limitations in daily activities and quality of life. The absence of a systematic comparison between patients with\/without anti\u2010MAG IgM polyneuropathy, no disease\u2010specific functional metric, and lack of international consensus regarding assessment and treatment of these patients are factors obstructing future clinical trials. Therefore, it was decided to develop an interval Rasch\u2010built activity\/participation scale specifically for IgM polyneuropathy \u00b1anti\u2010MAG (IgM\u2010RODS) and examine its clinimetric properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pre\u2010phase IgM\u2010RODS questionnaire containing 146 activity\/participation items, based on the WHO International Classification of Functioning, Disability and Health, was completed by participants (\u2265\u200918\u2009years) of the IMAGiNe observational registry that fulfilled international criteria for IgM\u2010polyneuropathy \u00b1anti\u2010MAG. Data was subjected to Rasch analyses, and reliability\/validity studies were performed as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pre\u2010RODS data of 259 subjects (originating from 8 different countries) underwent quality assessment, and 244 remaining records were submitted to the Rasch model, evidencing the model's expectations. Based on requirements like exceeding fit residuals, misfit statistics, item bias, local dependency, and less face validity, we systematically removed items until the final 36\u2010item IgM\u2010RODS fulfilled all Rasch requirements and showed acceptable test\u2013retest reliability, cross\u2010cultural, construct and discriminant validity, and unidimensionality. Compared to the Inflammatory\u2010RODS, the IgM\u2010RODS showed lower standard errors across the metric, indicating greater sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The 36\u2010item IgM\u2010RODS is a disease\u2010specific interval measure suitable for detecting functional deficits in patients with IgM\u2010polyneuropathy \u00b1anti\u2010MAG. Future studies are needed to determine its responsiveness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jns.70059","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:40:59Z","timestamp":1758613259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rasch\u2010Built Overall Disability Scale for <scp>IgM<\/scp>\u2010Associated Polyneuropathy With and Without Anti\u2010<scp>MAG<\/scp> Antibodies: <scp>IgM<\/scp>\u2010<scp>RODS<\/scp>"],"prefix":"10.1111","volume":"30","author":[{"given":"Tatiana","family":"Hamadeh","sequence":"first","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+, Mental Health and Neuroscience Research Institute  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes P. M.","family":"van de Mortel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke G. J.","family":"Hoeijmakers","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+, Mental Health and Neuroscience Research Institute  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Cornblath","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander F. J. E.","family":"Vrancken","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina G.","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center+, Mental Health and Neuroscience Research Institute  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette C.","family":"Notermans","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-0288","authenticated-orcid":false,"given":"Perry T. C.","family":"van Doormaal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Center Rudolph Magnus University Medical Center Utrecht  Utrecht the Netherlands"},{"name":"Department of Neurology Tergooi Medical Center  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar S. 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