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Motor fatigability, characterized by a decline in maximal muscle force, is common in neuromuscular disorders but remains underexplored in children with CMT. This study aimed to evaluate the feasibility of a motor fatigability test using a bulb dynamometer in children and adolescents with CMT1A, assess test\u2013retest reliability, and compare handgrip pressure, electromyographic parameters, perceived effort, and time to exhaustion between CMT1A and typically developing peers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational cross\u2010sectional study included 107 children (aged 8\u201316\u2009years; 19 with CMT1A and 88 typically developing). Participants performed a handgrip motor fatigability test using a bulb dynamometer, involving repetitive maximum voluntary isometric contractions (MVICs) at one\u2010second intervals until exhaustion, with simultaneous electromyographic monitoring. Test\u2013retest reliability was assessed using Bland\u2013Altman plots and the Intraclass Correlation Coefficient (ICC). For comparisons between groups and test phases, ANCOVA and linear mixed\u2010effects models were adjusted for sex, age, height, and weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A hundred and four children completed the test. The protocol was feasible, with both groups reaching significant exhaustion in 4\u2009min and showing a significant decline in handgrip pressure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The decline in median power frequency observed during the fatigue test indicated reduced neural activation in both groups. The ICC was 0.824, indicating good test\u2013retest reliability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The protocol shows promise for monitoring disease progression and treatment effects in children with CMT1A, and may serve as a functional marker. Future studies should include other CMT types.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70061","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T15:44:04Z","timestamp":1759506244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Easy Handgrip Test as a Tool for Assessing Motor Fatigability in Children With Charcot\u2010Marie\u2010Tooth Disease Type\n                    <scp>1A<\/scp>"],"prefix":"10.1111","volume":"30","author":[{"given":"Ester da Silva","family":"Estevam","sequence":"first","affiliation":[{"name":"Graduation of the Physiotherapy Course Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0400-0767","authenticated-orcid":false,"given":"Emanuela Juvenal","family":"Martins","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation and Functional Performance Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-026X","authenticated-orcid":false,"given":"Camila Scarpino Barboza","family":"Franco","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation and Functional Performance Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoliny Lisandra Teixeira","family":"Cruz","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation and Functional Performance Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tenysson Will","family":"de Lemos","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1485-3771","authenticated-orcid":false,"given":"Pedro Jos\u00e9","family":"Tomaselli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Sciences Behavior Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson Marques","family":"Junior","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Sciences Behavior Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-0718","authenticated-orcid":false,"given":"Ana Claudia","family":"Mattiello\u2010Sverzut","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318834"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000474"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443706"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2025.03.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2008.08.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12198"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.964254"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12582"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.34282"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.09.126"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-964984"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2013.05.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8373917"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21493"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23366"},{"key":"e_1_2_8_17_1","article-title":"Proof of Concept of the Ability of the Kinect to Quantify Upper Extremity Function in Dystrophinopathy","volume":"5","author":"Lowes L. 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