{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:20:15Z","timestamp":1789237215606,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Oxaliplatin (OHP) induced peripheral neurotoxicity (OIPN) is a complex spectrum comprising an acute and a chronic form. Acute OIPN leads to unpleasant transient sensations in the 24\u201372\u2009h after chemotherapy, due to a temporary dysfunction in ion channels (i.e., axonal hyperexcitability in the absence of anatomical damage). Whereas chronic OIPN is characterized by painful manifestations. Literature data showed that a more pronounced acute OIPN could be an early predictor of chronic OIPN; thus, acute OIPN is becoming a possible target to prevent chronic OIPN. We went back to the bench side to characterize the complexity of painful phenomena experienced by OHP\u2010treated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Female OHP\u2010treated (3\u2009mg\/Kg, 2qwx4ws, iv) and control rats (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910\/group) were studied. Acute OIPN was detected via nerve excitability testing (NET), whereas chronic OIPN was assessed via behavioral tests, nerve conduction studies (NCS), and neuropathology (including immunohistochemistry on lumbar spinal cord specimens) both at the end of the full chemotherapy treatment (4\u2009weeks) and at 6\u2009weeks of follow\u2010up. NET was also performed 1\u2009week after treatment completion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NET alterations related to acute OIPN were resolved within a week after chemotherapy. Whereas, chronic OIPN encountered only partial recovery over time, with prominent small fiber damage. Immunolabeling of the spinal cord at the end of treatment and after the follow\u2010up period was consistent with persistent neuropathic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Our data supports the statement that unpleasant manifestations due to acute and chronic OIPN mirror different underlying phenomena and assessment as two separate entities should be considered in both clinical and preclinical studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70078","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T14:05:17Z","timestamp":1763215517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Characterization of Oxaliplatin\u2010Induced Peripheral Neurotoxicity: The Complex Spectrum of Painful Manifestations"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6438-286X","authenticated-orcid":false,"given":"Eleonora","family":"Pozzi","sequence":"first","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery  Monza Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-7861","authenticated-orcid":false,"given":"Maria Pina","family":"Serra","sequence":"additional","affiliation":[{"name":"Section of Cytomorphology, Department of Biomedical Sciences, University of Cagliari  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-313X","authenticated-orcid":false,"given":"Marianna","family":"Boi","sequence":"additional","affiliation":[{"name":"Section of Cytomorphology, Department of Biomedical Sciences, University of Cagliari  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Francesca","family":"Kraus","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery  Monza Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Quartu","sequence":"additional","affiliation":[{"name":"Section of Cytomorphology, Department of Biomedical Sciences, University of Cagliari  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-2406","authenticated-orcid":false,"given":"Guido","family":"Cavaletti","sequence":"additional","affiliation":[{"name":"Experimental Neurology Unit, School of Medicine and Surgery  Monza Italy"},{"name":"NeuroMI (Milan Center for Neuroscience)  Milan 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