{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:17:00Z","timestamp":1778635020689,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n Chronic inflammatory demyelinating polyradiculoneuropathy (\n CIDP<\/jats:styled-content>\n ) is a common, treatable, autoimmune, neuropathy frequently misdiagnosed. The complex electrodiagnostic (\n EDX<\/jats:styled-content>\n ) criteria required for diagnosis are challenging to apply in routine practice. This study evaluates the effectiveness of a machine\u2010assisted\n EDX<\/jats:styled-content>\n tool in real\u2010time identification of demyelinating nerve conduction studies (\n NCS<\/jats:styled-content>\n ) stipulated by 2021\u2010\n EAN<\/jats:styled-content>\n \/\n PNS CIDP<\/jats:styled-content>\n criteria in conjunction with an online\n CIDP<\/jats:styled-content>\n clinical probability calculator.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We prospectively evaluated 100 consecutive patients with referral or\n EDX<\/jats:styled-content>\n diagnosis of polyradiculoneuropathy beginning January 1, 2024. Fifty patients were included, each from Jacksonville and Rochester Mayo Clinics. Routine electromyography (\n EMG<\/jats:styled-content>\n ) reports were compared to a machine\u2010assisted support tool applying 2021\u2010\n EAN<\/jats:styled-content>\n \/\n PNS CIDP EDX<\/jats:styled-content>\n criteria to\n NCS<\/jats:styled-content>\n assessing demyelination. The\n EDX<\/jats:styled-content>\n \u2010assistant performance was compared to the final clinical diagnosis and our previously reported online\n CIDP<\/jats:styled-content>\n clinical prediction tool (\n https:\/\/news.mayocliniclabs.com\/cidp\u2010calculator\/<\/jats:ext-link>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 100 patients (60% male; median age 64), 30 had a final clinical\n CIDP<\/jats:styled-content>\n diagnosis with 29 having intravenous immunoglobulin follow\u2010up; 27 (93%) improved and 2 (7%) stabilized. Routine\n EMGs<\/jats:styled-content>\n reported demyelination in 14 of 30 (47%), with 46% sensitivity and 79% specificity. The\n EDX<\/jats:styled-content>\n \u2010assistant identified\n CIDP<\/jats:styled-content>\n demyelination in 28 of 30 (93%), with 93% sensitivity and 57% specificity. The clinical calculator detected\n CIDP<\/jats:styled-content>\n in 30 of 30 (100%) with 86% specificity, increasing to 94% after excluding false positives lacking demyelinating features on the\n EDX<\/jats:styled-content>\n tool.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n A real\u2010time machine\u2010assisted EDX support tool, used with a clinical web\u2010based calculator, streamlines CIDP assessment by improving standardized identification of 2021\u2010EAN\/PNS CIDP demyelinating NCS criteria and aiding clinical decisions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jns.70084","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:05:37Z","timestamp":1766127937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective Evaluation of Machine\u2010Assisted Electrophysiologic and Online Clinical Diagnostic Support Tools in Chronic Inflammatory Demyelinating Polyradiculoneuropathy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5155-4371","authenticated-orcid":false,"given":"Michael P.","family":"Skolka","sequence":"first","affiliation":[{"name":"Mayo Clinic Department of Neurology Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Swart","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital University of Sydney Sydney Australia"},{"name":"Mayo Clinic Department of Neurology Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-1687","authenticated-orcid":false,"given":"Shahar","family":"Shelly","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Neurology Rochester Minnesota USA"},{"name":"Department of Neurology and the Technion Institute of Technology Rambam Medical Center Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thapat","family":"Wannarong","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences University of Nebraska Medical Center Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"St\u00e5lberg","sequence":"additional","affiliation":[{"name":"Cadwell Industries, Inc Kennewick Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"St\u00e5lberg","sequence":"additional","affiliation":[{"name":"Cadwell Industries, Inc Kennewick Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abe","family":"Gardner","sequence":"additional","affiliation":[{"name":"Cadwell Industries, Inc Kennewick Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Price","sequence":"additional","affiliation":[{"name":"Cadwell Industries, Inc Kennewick Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-5824","authenticated-orcid":false,"given":"Ruple S.","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Neurology Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyanshu","family":"Dubey","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Neurology Rochester Minnesota USA"},{"name":"Mayo Clinic Department of Laboratory Medicine and Pathology Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Mills","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Laboratory Medicine and Pathology Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Mandrekar","sequence":"additional","affiliation":[{"name":"Clinical Trials and Biostatistics, Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4012-8856","authenticated-orcid":false,"given":"Christopher J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Neurology Rochester Minnesota USA"},{"name":"Mayo Clinic Department of Laboratory Medicine and Pathology Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494291"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181aaea47"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120478"},{"issue":"11","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0025-6196(25)09732-0","article-title":"Chronic Inflammatory Polyradiculoneuropathy","volume":"50","author":"Dyck P. J.","year":"1975","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02930.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12455"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1085-9489.2005.10302.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10287-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001833"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14796"},{"issue":"1","key":"e_1_2_10_12_1","article-title":"Chronic Inflammatory Demyelinating Polyneuropathy: A Narrative Review of a Systematic Diagnostic Approach to Avoid Misdiagnosis","volume":"17","author":"Roman\u2010Guzman R. M.","year":"2025","journal-title":"Cureus"},{"issue":"3","key":"e_1_2_10_13_1","first-page":"127","article-title":"Treatment Patterns and Costs of Chronic Inflammatory Demyelinating Polyneuropathy: A Claims Database Analysis","volume":"12","author":"Guptill J. T.","year":"2019","journal-title":"American Health & Drug Benefits"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318714"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12682"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2021-003070"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011792"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.653734"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24207"},{"key":"e_1_2_10_20_1","first-page":"159","volume-title":"Clinical Neurophysiology","author":"Daube J. R.","year":"2002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.70017"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000212523"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-024-01357-9"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.70084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jns.70084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:19:45Z","timestamp":1775636385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jns.70084"],"URL":"https:\/\/doi.org\/10.1111\/jns.70084","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70084"}}