{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:48:46Z","timestamp":1782103726554,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Bortezomib\u2010induced peripheral neuropathy (BIPN) remains a common treatment side effect in patients with multiple myeloma (MM). Data from rodent models indicate a role of proinflammatory cytokines in BIPN pathophysiology, making them potential therapeutic targets. We therefore tested cytokine levels throughout the course of BIPN in a cohort of MM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an interim analysis of a monocentric, non\u2010randomized, observational study including 113 patients with MM. Three groups of patients\u2014within their first cycle of BTZ treatment (FC), with ongoing BTZ treatment at the time of recruiting (OT), and with BTZ treatment in the past (PT)\u2014were compared to controls. Sixteen FC patients were followed up for a median of 6\u2009months. Serum TNF\u2010\u03b1, IL\u20106, and CCL2, the cytokines most often implied in the animal models, were analyzed via the ELLA device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CCL2 levels were not different among our patient groups or in comparison with healthy controls. Compared to healthy controls, the FC group had the highest IL\u20106 levels, followed by the PT and then the OT group. The FC group also had higher TNF\u2010\u03b1 levels compared to all other groups. Six\u2009months after inclusion, patients showed a decrease in TNF\u2010\u03b1 levels compared to their baseline. There was no correlation between TNF\u2010\u03b1 levels and neuropathy severity or impairment in daily life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Factors related to MM may influence systemic cytokine levels in BIPN patients, limiting conclusions on their role in BIPN pathophysiology and their utility as drug targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70090","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:31:43Z","timestamp":1769239903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytokine Dynamics in Bortezomib\u2010Induced Peripheral Neuropathy: Challenges in Translating Preclinical Findings to Humans"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-2281","authenticated-orcid":false,"given":"Nadine","family":"Cebulla","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Runau","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Flamm","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Terhorst","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"J\u00e4hnel","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"G\u00fcse","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Giordani","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Wieser","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Schoch","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Luise","family":"Reinle","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Gommersbach","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Papagianni","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-7700","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kristin","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Pain Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Rittner","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Pain Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine University Hospital W\u00fcrzburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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