{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:10Z","timestamp":1782103750225,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is classically a monophasic illness. In resource\u2010limited settings, patients with GBS are not routinely followed up. However, these patients may suffer from residual symptoms and disability. In this study, we assessed the trajectory of recovery and burden of residual symptoms in patients who developed GBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective cohort study was conducted at the National Hospital of Sri Lanka from January 1, 2020 to April 1, 2025. We assessed the patients during the illness and then at 1, 3, and 6\u2009months after discharge. The primary outcome was the GBS Disability Score (0 [\n                      <jats:italic>no disability<\/jats:italic>\n                      ]\u20136 [\n                      <jats:italic>death<\/jats:italic>\n                      ]), and the secondary outcomes were the individual residual symptoms. All patients with GBS were included. The serial improvement of the GBS Disability Score was assessed using the generalized equation estimate. The burden of residual symptoms was given as percentages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 144 patients with GBS (mean age 46.2\u2009\u00b1\u200917.3\u2009years; male:female 0.92), and 67 completed the follow\u2010up. There was no in\u2010hospital mortality; one patient (1.5%) died within 6\u2009months. The disability improved significantly, with only 5.9% unable to walk independently at 6\u2009months. Increasing age and axonal variants (AMAN\/AMSAN, 37%) were independent negative predictors of recovery. The residual symptoms at 6\u2009months included positive sensory symptoms (42.6%), fatigue (30.9%), and subjective limb weakness (29.4%). Forty\u2010eight percent had to make some change in their occupation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Although many patients achieve motor recovery, there is a high burden of residual symptoms at 6\u2009months in patients with GBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70105","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:47:13Z","timestamp":1773006433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trajectory of Recovery and Burden of Residual Symptoms Following Guillain\u2013Barr\u00e9 Syndrome: A Single\u2010Center Prospective Cohort Study From Sri Lanka"],"prefix":"10.1111","volume":"31","author":[{"given":"Bimsara","family":"Senanayake","sequence":"first","affiliation":[{"name":"Institute of Neurology National Hospital of Sri Lanka  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5849-8962","authenticated-orcid":false,"given":"Arun","family":"Rajaratnam","sequence":"additional","affiliation":[{"name":"Institute of Neurology National Hospital of Sri Lanka  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilani","family":"Thennakoon","sequence":"additional","affiliation":[{"name":"Institute of Neurology National Hospital of Sri Lanka  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimasha","family":"Ekanayake","sequence":"additional","affiliation":[{"name":"Institute of Neurology National Hospital of Sri Lanka  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-2553","authenticated-orcid":false,"given":"Pramith","family":"Ruwanpathirana","sequence":"additional","affiliation":[{"name":"Institute of Neurology National Hospital of Sri Lanka  Colombo Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)00339\u20101"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1114525"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013139"},{"key":"e_1_2_13_5_1","first-page":"339","article-title":"Early Recognition and Outcome of Severe Guillain\u2013Barr\u00e9 Syndrome","volume":"88","author":"Walgaard C.","year":"2017","journal-title":"Journal of Neurology, Neurosurgery, and 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