{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:48:43Z","timestamp":1782103723557,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003197","name":"Agenzia Italiana del Farmaco, Ministero della Salute","doi-asserted-by":"publisher","award":["AIFA\u20102016\u201002364540"],"award-info":[{"award-number":["AIFA\u20102016\u201002364540"]}],"id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Rituximab has been proposed as a potential treatment in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but formal evidence regarding its clinical effectiveness is weak. The CIDPRIT trial found no clinical benefit in comparison with placebo, but secondary analyses suggested some beneficial effect. Analysis of serum neurofilament light chain (sNfL) may provide evidence to support rituximab's effect on CIDP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a post hoc analysis of sNfL levels from the CIDPRIT trial participants. Blood samples were collected at baseline, month 6, and 12. sNfL was measured using Simoa technology. Geometric means and z\u2010scores were compared across groups. Linear mixed\u2010effects models and survival analyses were used to evaluate treatment effects and clinical correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      33 participants were included (18 rituximab, 15 placebo). Baseline sNfL was significantly higher in the rituximab group (11.51 vs. 6.67\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). While between\u2010group differences over time were not statistically significant, rituximab\u2010treated patients showed stable sNfL levels at month 6 and a slight decrease at month 12, contrasting with modest increases in the placebo group. Among rituximab\u2010treated patients who remained clinically stable at month 12, sNfL showed a non\u2010significant decline by 31%. No significant associations were found between baseline sNfL and clinical worsening. NfL levels correlated with neurophysiological parameters of axonal damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The analysis did not demonstrate biomarker\u2010based evidence of rituximab efficacy in CIDP. However, observed trends suggest a possible biological effect in reducing axonal injury in a subset of patients. Further studies are needed to clarify the role of sNfL in treatment monitoring and patient stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70107","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:04:06Z","timestamp":1770379446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Rituximab on Neurofilament Levels in\n                    <scp>CIDP<\/scp>\n                    : Results From the\n                    <scp>CIDPRIT<\/scp>\n                    Randomized Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-6792","authenticated-orcid":false,"given":"Pietro Emiliano","family":"Doneddu","sequence":"first","affiliation":[{"name":"Neuromuscular and Neuroimmunology Unit IRCCS Humanitas Research Hospital  Milan Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-1018","authenticated-orcid":false,"given":"Roger","family":"Collet\u2010Vidiella","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Department of Neurology  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Gallo","sequence":"additional","affiliation":[{"name":"Neuromuscular and Neuroimmunology Unit IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Cocito","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1442-9604","authenticated-orcid":false,"given":"Fiore","family":"Manganelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Odontostomatology University of Naples \u2018Federico II\u2019  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Falzone","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Department of Neurology Institute of Experimental Neurology (INSPE), san Raffaele Scientific Institute  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora Dalla","family":"Bella","sequence":"additional","affiliation":[{"name":"Unit of Neuroalgology IRCCS Foundation \u2018Carlo Besta\u2019 Neurological Institute  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Neurology Clinic IRCCS Ospedale Policlinico San Martino Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mazzeo","sequence":"additional","affiliation":[{"name":"Department of 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