{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:48:48Z","timestamp":1782186528644,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>To determine the role of phrenic nerve conduction studies (NCS) in identifying subtypes of Guillain\u2010Barr\u00e9 syndrome (GBS) and to investigate the correlations between phrenic NCS and clinical and respiratory scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A clinical evaluation was conducted on 23 patients diagnosed with GBS, encompassing the Medical Research Council (MRC) sum scores, GBS disability scores, and Erasmus GBS Respiratory Insufficiency Scores (EGRIS). Electrodiagnostic studies (EDX) were conducted twice and bilateral phrenic NCSs once within the 6\u2009weeks after symptom onset. The latency, peak\u2010to\u2010peak amplitude, and negative peak area of phrenic compound muscle action potential (CMAP) elicited using surface electrodes were measured, and the values indicating prolonged latency (\u2265\u2009110%\u2013130% of upper limit of normal (ULN)) and\/or prolonged negative peak duration (\u2265\u2009130% of ULN) were considered as demyelinating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Phrenic NCSs revealed 87.0% sensitivity and 89.5% specificity in the diagnosis of demyelinating subtype (cut\u2010off value of latency 8.6\u2009ms). Most of the phrenic CMAP parameters revealed moderate correlations with clinical scores and with the results of median and ulnar EDX studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Besides its importance for having correlations with clinical and respiratory features, phrenic NCS may improve the diagnostic sensitivity in differentiating GBS subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70131","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:24:37Z","timestamp":1780403077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significance of Phrenic Nerve Conduction Study in the Electrodiagnosis of\n                    <scp>G<\/scp>\n                    uillain\n                    <scp>B<\/scp>\n                    arr\u00e9 Syndrome"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-1565","authenticated-orcid":false,"given":"Volkan","family":"Tasdemir","sequence":"first","affiliation":[{"name":"Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8792-2929","authenticated-orcid":false,"given":"Nermin Gorkem","family":"Sirin","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-3552","authenticated-orcid":false,"given":"Sezin Alpayd\u0131n","family":"Baslo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Atakli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-5944","authenticated-orcid":false,"given":"Aysun","family":"Soysal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-4172","authenticated-orcid":false,"given":"Arman","family":"Cakar","sequence":"additional","affiliation":[{"name":"Neuromuscular Unit, Departments of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-676X","authenticated-orcid":false,"given":"Hacer Durmus","family":"Tekce","sequence":"additional","affiliation":[{"name":"Neuromuscular Unit, Departments of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Parman","sequence":"additional","affiliation":[{"name":"Neuromuscular Unit, Departments of Neurology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-0559","authenticated-orcid":false,"given":"Mehmet Baris","family":"Baslo","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Emre","family":"Oge","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Kocasoy","family":"Orhan","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Clinical Neurophysiology, Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90606-P"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.07.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.03.048"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.1.74"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.12.047"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy232"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000184589.62101.b9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.2007.00874.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.17712\/1658-3183.1918"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_345_17"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.3.245"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27918"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.2.191"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12612"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92644-2"},{"issue":"11","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/mus.880141111","article-title":"Interobserver Agreement in the Assessment of Muscle Strength and Functional Abilities in Guillain\u2010Barr\u00e9 Syndrome","volume":"14","author":"Kleyweg R. P.","year":"1991","journal-title":"Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21976"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880180311"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.18071\/isz.79.0035"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20887"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282X20170153"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26414"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27172"}],"container-title":["Journal of the Peripheral Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.70131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jns.70131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jns.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:18:25Z","timestamp":1782184705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jns.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jns.70131"],"URL":"https:\/\/doi.org\/10.1111\/jns.70131","archive":["Portico"],"relation":{},"ISSN":["1085-9489","1529-8027"],"issn-type":[{"value":"1085-9489","type":"print"},{"value":"1529-8027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70131"}}