{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:49:49Z","timestamp":1790603389843,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG ME 3696\/3"],"award-info":[{"award-number":["DFG ME 3696\/3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>This study aimed to systematically phenotype autonomic nervous system (ANS) involvement in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), monoclonal gammopathy of undetermined significance\u2010associated neuropathy (MGUS\u2010PNP), Charcot\u2013Marie\u2013Tooth disease Type 1A (CMT1A), and hereditary neuropathy with liability to pressure palsies (HNPP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Autonomic symptoms were assessed using the SCales for Outcomes in Parkinson's Disease\u2010Autonomic Dysfunction (SCOPA\u2010AUT). Muscle strength and functional disability were evaluated using the Medical Research Council (MRC) scale, the Inflammatory Neuropathy Cause and Treatment (INCAT) disability scale, and the Overall Neuropathy Limitation Scale (ONLS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 343 participants were included: 98 with CIDP (mean age: 59.2\u2009\u00b1\u200913.2\u2009years), 51 with MGUS\u2010PNP (66.0\u2009\u00b1\u200911.3\u2009years), 51 with CMT1A (51.2\u2009\u00b1\u200913.1\u2009years), 18 with HNPP (40.6\u2009\u00b1\u200915.1\u2009years), and 125 healthy controls (58.2\u2009\u00b1\u200913.3\u2009years). Compared with healthy controls, patients with CIDP, MGUS\u2010PNP, and CMT1A showed significantly higher total SCOPA\u2010AUT scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Distinct, disease\u2010specific ANS symptom patterns were observed across neuropathy subtypes. Overall disability was independently associated with overall autonomic symptom burden in MGUS\u2010PNP (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and CMT1A (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In CIDP, patients with active disease showed higher autonomic symptom burden than those with inactive disease (12.7\u2009\u00b1\u200911.7 vs. 8.6\u2009\u00b1\u20097.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Patients with CIDP, MGUS\u2010PNP, and CMT1A exhibit a substantial autonomic symptom burden with distinct disease\u2010specific ANS patterns. These findings highlight the relevance of autonomic dysfunction in immune\u2010mediated and hereditary neuropathies and warrant further studies to clarify their clinical and prognostic significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70135","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:36:22Z","timestamp":1781922982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autonomic Nervous System Phenotyping Across Chronic Demyelinating Peripheral Neuropathies: A Comparative Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-703X","authenticated-orcid":false,"given":"Bogdan","family":"Bjelica","sequence":"first","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"},{"name":"PRACTIS Clinician Scientist Program, Dean's Office for Academic Career Development Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Todorovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic, University Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-0779","authenticated-orcid":false,"given":"Ivo","family":"Bozovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic, University Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-1444","authenticated-orcid":false,"given":"Aleksa","family":"Palibrk","sequence":"additional","affiliation":[{"name":"Neurology Clinic, University Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic, University Clinical Center Kragujevac  Kragujevac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Basta","sequence":"additional","affiliation":[{"name":"Neurology Clinic, University Clinical Center of Serbia  Belgrade Serbia"},{"name":"Faculty of Medicine, University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-556X","authenticated-orcid":false,"given":"Stojan","family":"Peric","sequence":"additional","affiliation":[{"name":"Neurology Clinic, University Clinical Center of Serbia  Belgrade Serbia"},{"name":"Faculty of Medicine, University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"407","volume-title":"Handbook of Clinical Neurology","author":"Gibbons C. 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