{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:02:39Z","timestamp":1790071359941,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OR.17\u201010"],"award-info":[{"award-number":["W.OR.17\u201010"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OR.22\u201002"],"award-info":[{"award-number":["W.OR.22\u201002"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Chronic axonal polyneuropathy is a common disorder that often remains undiagnosed. Early detection may enhance treatment of underlying risk factors and prevent long\u2010term complications. The Erasmus\u2010Polyneuropathy symptom score (E\u2010PSS) is a simple and rapid screening tool, consisting of six questions (score ranges 0\u201314). This study aims to validate the E\u2010PSS in a non\u2010academic population and compare its performance with the commonly used Michigan Neuropathy Screening Instrument questionnaire (MNSIq).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This validation study was performed at two non\u2010academic neurology outpatient clinics in the Netherlands. Patients visiting the outpatient clinic, regardless of the reason for referral, were eligible for inclusion if aged \u2265\u200918\u2009years and able to fill in the questionnaire. The gold standard definition of chronic axonal polyneuropathy was based on the diagnosis made by the treating physician. The discriminative performance was evaluated using the area under the curve (AUC) of the receiver operating curves (ROC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From February 2020 until October 2021, 818 participants were included, of whom 222 had chronic axonal polyneuropathy (27%). Median age was 62\u2009years (IQR 49\u201373) and 59% were female (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009479). The median E\u2010PSS score in participants with polyneuropathy was 6 (IQR 3\u20138) and in participants without polyneuropathy 1 (IQR 0\u20134). The performance of the E\u2010PSS was good (AUC 0.81, 95% CI 0.77\u20130.84) and better than the MNSIq (AUC 0.65, 95% CI 0.61\u20130.69) (The DeLong test;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The E\u2010PSS is a fast and easy\u2010to\u2010use questionnaire with good AUC\u2010determined discriminative performance between participants with and without chronic axonal polyneuropathy in non\u2010academic neurology outpatient settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70143","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:15:03Z","timestamp":1783984503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Erasmus\u2014Polyneuropathy Symptom Score for the Screening of Chronic Axonal Polyneuropathy: A Validation Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-0564","authenticated-orcid":false,"given":"Noor E.","family":"Taams","sequence":"first","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Neurology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6937-4233","authenticated-orcid":false,"given":"Merel","family":"Huijg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Neurology Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique H.","family":"Vermeij","sequence":"additional","affiliation":[{"name":"Department of Neurology Franciscus Gasthuis &amp; Vlietland  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-500X","authenticated-orcid":false,"given":"Krista","family":"Kuitwaard","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Neurology Albert Schweitzer Hospital  Dordrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rens","family":"Hanewinckel","sequence":"additional","affiliation":[{"name":"Department of Neurology Erasmus University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Neurology Canisius Wilhelmina Hospital  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6089-9896","authenticated-orcid":false,"given":"Janet","family":"de Beukelaar","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Schweitzer Hospital  Dordrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-8436","authenticated-orcid":false,"given":"Evan L.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-6748","authenticated-orcid":false,"given":"Brian C.","family":"Callaghan","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-8585","authenticated-orcid":false,"given":"M. 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