{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:59:10Z","timestamp":1790305150486,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF 18OC0053006"],"award-info":[{"award-number":["NNF 18OC0053006"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Peripheral Nervous Sys"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an immune\u2010mediated neuropathy that may cause persistent disability despite immunoglobulin treatment. Ion channel dysfunction has been demonstrated in CIDP, but no therapies specifically target this mechanism. We investigated whether fampridine improves clinical function and electrophysiological measures in CIDP patients with residual symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this two\u2010center, randomized, double\u2010blind, placebo\u2010controlled crossover trial, patients with CIDP receiving stable subcutaneous or intravenous immunoglobulin were assigned to 4\u2009weeks of fampridine (10\u2009mg twice daily) or placebo, separated by a washout period. Co\u2010primary outcomes were changes in Six\u2010Spot\u2010Step Test (SSST) and Nine\u2010Hole Peg Test (9\u2010HPT). Secondary outcomes included clinical scores, patient\u2010reported outcomes, nerve conduction studies, and nerve excitability testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight patients were included in the study. No significant differences were observed between fampridine and placebo for SSST (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.154) or 9\u2010HPT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.857). Grip strength and R\u2010ODS worsened during fampridine compared with placebo (Bonferroni\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007 for both), while other clinical outcomes showed no differences. Median nerve CMAP amplitude with proximal stimulation increased significantly during fampridine treatment (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040). No significant changes were observed in other electrophysiological variables, including nerve excitability testing. No serious adverse events occurred and adverse effects were predominantly mild.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Our study did not provide evidence that fampridine improves clinical function in CIDP patients with residual disability during stable immunoglobulin therapy. Targeting ion channel dysfunction in CIDP remains of interest, but alternative strategies may be required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jns.70172","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:21:47Z","timestamp":1790302907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fampridine for Symptomatic Treatment in Chronic Inflammatory Demyelinating Polyneuropathy: A Randomized, Double\u2010Blinded, Placebo\u2010Controlled Crossover Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-0229","authenticated-orcid":false,"given":"Peter N\u00f8rregaard","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Neurology Odense University Hospital  Odense Denmark"},{"name":"Neurological Research Unit, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-9768","authenticated-orcid":false,"given":"Lars","family":"Markvardsen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8495-9769","authenticated-orcid":false,"given":"Hatice","family":"Tankisi","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-6948","authenticated-orcid":false,"given":"Thomas","family":"Kr\u00f8ig\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital  Odense Denmark"},{"name":"Neurological Research Unit, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0357-8628","authenticated-orcid":false,"given":"S\u00f8ren","family":"Sindrup","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital  Odense Denmark"},{"name":"Neurological Research Unit, Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(10)70041\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2014.10.009"},{"issue":"8","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1001\/archneur.1989.00520440064022","article-title":"Chronic Inflammatory Demyelinating Polyradiculoneuropathy. 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